FKS与光滑念珠菌棘白菌素耐药  

Advances in research on FKS mutation and echinocandin resistance of Candida glabrata

作　　者：高盈[1] 佘晓东[1] 刘维达[1] 

机构地区：[1]北京协和医学院中国医学科学院皮肤病研究所真菌科,南京210042

出　　处：《中国真菌学杂志》2014年第6期364-367,363,共5页Chinese Journal of Mycology

基　　金：国家973项目(2013CB531605);江苏省自然基金青年基金(BK20130063)

摘　　要：近年来,光滑念珠菌侵入性感染及其耐棘白菌素治疗失败的病例不断增多,深入研究其耐药机制十分有必要。Fks突变在光滑念珠菌棘白菌素耐药发生的过程中有着极其重要的地位,其与棘白菌素的MIC值及体内治疗结果密切相关,且有很多因素可以对Fks突变的发生及其作用产生影响。The proportion of systemic fungal infections in humans caused by C. glabrata has increased significantly in recent years,and in the same time,cases about echinocandins therapeutic failure to this pathogen has been reported more and more. FKS mutation has a significant role in the growth of MIC values and echinocandin resistance,and a lot of elements can effect it.

关 键 词：光滑念珠菌 Fks突变 MIC 棘白菌素耐药 

分 类 号：R379.4[医药卫生—病原生物学]