慢性盐负荷对成年人血清肾胺酶的影响  

Effect of chronic salt loading on serum renalase level in adults

作　　者：王宝莉[1,2] 汪洋[1] 牟建军[1] 杨璠[1] 谢冰清[1] 董珍珍[1] 褚超[1] 刘富强[1] 

机构地区：[1]西安交通大学第一附属医院心内科,陕西西安710061 [2]西安市第一医院心内科,陕西西安710002

出　　处：《内科理论与实践》2014年第6期390-393,共4页Journal of Internal Medicine Concepts & Practice

基　　金：国家重点基础研究发展计划(973计划)课题(课题编号:2012CB517804);国家自然科学基金资助项目(项目编号:81370357)

摘　　要：目的：观察慢性盐负荷对成年人血清肾胺酶浓度的影响。方法：选取42例28～65岁的成年人参与为期2周的慢性盐负荷试验，包括3d基线调查及低盐饮食、高盐饮食各7d的研究。每个阶段均测量血压，并收集血、尿标本。测定24h尿钠、钾含量；血清肾胺酶采用酶联免疫吸附（ELISA）法测定。结果：与基线期相比，低盐饮食可显著升高受试者血清肾胺酶水平[（5．10±0．181比（8．12±0．42）mg／L，P〈0．01]：高盐负荷后，受试者血清肾胺酶的浓度[（5．65±0．17）mg／L]较低盐期明显下降（P〈0．01），血清肾胺酶浓度与24h尿钠排泄存在负相关关系（r=-0．459，P〈0．01）。结论：成年人膳食盐的摄入可能影响血清肾胺酶的浓度，发挥血压的调控作用。Objective To study the effect of chronic salt loading on serum renalase levels in adults. Methods Forty- two healthy subjects （28-65 years of age） were enrolled, and all were sequentially maintained on a low-sah diet for 7 d （3.0 g/d of NaCI）, a high-salk diet for 7 d （18.0 g/d of NaCI）. On the last day of each period, the serum and 24 h urine samples were collected. Serum renalase was measured by enzyme linked immunosorbent assay （ELISA） kit. Results Serum renalase level was significantly higher during the low-sah diet period than the baseline level [（8.12±0.42） mg/L vs （5.10±0.18） mg/L, P〈0.01]. Renalase level decreased with the change from the low-salt to high-salt diet [（8.12±0.42）） mg/L vs （5.65±0.17） rag/L, P〈0.01]. There was a significant inverse correlation between serum renalase level and 24-h urinary sodium excretion （r=-0.459, P〈0.01 ）. Conclusions Variations in dietary salt intake might affect the serum renalase level in adults and play a role in regulation of blood pressure.

关 键 词：肾胺酶 盐 儿茶酚氨 血压 

分 类 号：R544.1[医药卫生—心血管疾病]