煤工尘肺患者血清中颗粒酶B抗体的表达及其意义  

The expression and significance of Anti-Gzm B in serum of coal workers with pneumoconiosis

作　　者：裴阳晴[1] 刘素娜[2] 暴磊[2] 张红义[2] 侯建永[2] 郝长付[2] 姚武[2] 

机构地区：[1]郑州大学第一附属医院检验科,河南郑州450052 [2]郑州大学公共卫生学院,河南郑州450001

出　　处：《河南医学研究》2014年第12期150-153,共4页Henan Medical Research

摘　　要：目的:检测煤工尘肺患者及接尘工人血清中颗粒酶B(Granzyme B,Gzm B)抗体的表达水平,探讨其在煤工尘肺发病过程中的意义。方法:采用ELISA法检测观察对象组、接尘组、病例组和健康对照组血清中Gzm B抗体的表达水平。结果:煤工尘肺患者血清中Gzm B抗体的表达量的OD值为(1.478±0.450),高于接尘组和对照组表达量的OD值(1.325±0.463)、(1.377±0.430),差异均有统计学意义(P<0.05)。壹期尘肺且工龄<25 a患者Gzm B抗体表达量OD值为(1.418±0.457),工龄>25患者Gzm B抗体表达量OD值为(1.534±0.443),差异具有统计学意义(P<0.05)。结论:煤工尘肺患者血清中Gzm B抗体表达水平增高且与接尘工龄正相关,提示血清中Gzm B抗体可能与煤工尘肺的发生发展及严重程度密切相关。Objective： To detect the anti-Gzm B levels in serum of CWP and workers exposed to dust,provide a basis for the study of pathogenesis of pneumoconiosis. Methods： 1 260 cases were selected and the expression levels of anti-Gzm B in serum were detected by ELISA. Results： The OD value of Gzm B in CWP group（ 1. 478 ± 0. 450） were higher than exposed group（ 1. 325 ±0. 463） and control group（ 1. 377 ± 0. 430）,the differences were statistically significant（ P〈0. 05）. The OD value of Gzm B in the first-stage pneumoconiosis patients with length of service less than 25 a was（ 1. 418 ± 0. 457）,lower than patients with length of service more than 25 a（ 1. 534 ±0. 443）,the differences were statistically significant（ P〈0. 05）. Conclusion： Anti-Gzm B may be involved in the development process of CWP.

关 键 词：煤工尘肺 颗粒酶B抗体 接尘工人 

分 类 号：R135.2[医药卫生—劳动卫生]