miRNA参与肝星状细胞活化及慢性肝病发展的作用机制研究进展  

Recent progress in the role of miRNA in hepatic stellate cells activation and the chronic hepatic diseases

作　　者：宋立莹[1,2] 彭向东[1] 王春江[1] 郭韧[1] 刘世坤[1,2] 

机构地区：[1]中南大学湘雅三医院药剂科 [2]中南大学药学院

出　　处：《中国临床药理学与治疗学》2014年第12期1422-1428,共7页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：中南大学研究生自主探索创新基金项目(2012ZZTS114)

摘　　要：微小RNA（microRNA.miRNA）为内源性短小（18～25个核苷酸组成）单链非编码RNA,通过与靶基因mRNA序列3＇末端非翻译区（3＇-UTR）结合抑制蛋白翻译过程或干扰mRNA降低靶蛋白水平,miRNA异常表达影响多种器官重构中细胞增殖及分化.近期研究表明miRNA这一转录后水平的调控分子参与各种慢性肝病发生发展,肝星状细胞的激活是导致早期肝损伤的关键因素,本文将就miRNA在肝星状细胞激活及慢性肝病发展中的作用作一系统综述.Small RNA （known as microRNA,miRNA） is single-stranded non-coding RNA （18-25 nucleotides length）,it regulates various proteins by targeting the 3＆#39;-untranslated region （3-UTR） of various transcripts,thus dysregulation of miRNA affects a wide range of processes such as cell proliferation and differentiation involved in organ remodeling processes.Current studies demonstrated that post-transcriptional effect of miRNA is involved in the development of chronic liver diseases,while hepatic stellate cells （HSCs） play a vital role in the primary formation of ECM and undergo progressive activation to become myofibroblasts （MFB）-like cells.The aim of this paper is to discuss the role of miRNA in hepatic stellate cells activation and the chronic hepatic diseases.

关 键 词：MIRNA 慢性肝病 肝星状细胞 

分 类 号：R966[医药卫生—药理学]