盐酸曲马多与高乌甲素术后自控镇痛疗效与安全性的meta分析  

Efficacy and safety of tramadol hydrochloride versus lappaconitine for patient-controlled analgesia:a meta-analysis

作　　者：刘艳红[1] 柯静[1] 钟卫华[1] 柯尊琼[1] 王林海[1] 

机构地区：[1]湖北医药学院附属人民医院药学部,湖北省十堰市442000

出　　处：《职业与健康》2015年第3期366-369,共4页Occupation and Health

摘　　要：目的系统评价盐酸曲马多与高乌甲素术后患者自控镇痛(PCA)的临床效果与安全性。方法计算机检索Pub Med、The Cochrane Library、CBM、CNKI和Wan Fang Data,收集盐酸曲马多与高乌甲素术后PCA的随机对照试验(RCT),对纳入的RCT进行资料提取和质量评估后,对能够进行定量合成的结果采用Rev Man 5.2软件进行meta分析。结果共纳入11个RCT,共689例患者,meta分析结果显示:1 VAS评分:曲马多与高乌甲素组术后2、4、8、12、24和48 h评分均无统计学差异。2安全性:高乌甲素组术后恶心呕吐、头晕嗜睡、尿潴留等不良反应(ADR)的发生率较盐酸曲马多组低。结论现有证据表明,盐酸曲马多与高乌甲素术后PCA均能获得满意的镇痛效果,但高乌甲素ADR发生率低。但鉴于纳入研究的局限性,对该研究结果的可靠性尚需展开更多高质量、大样本的RCT予以证实。[Objective]To evaluate the efficacy and safety of tramadol hydrochloride versus lappaconitine for patient-controlled analgesia（PCA）.[Methods]The randomized controlled trials（RCTs） about tramadol hydrochloride versus lappaconitine for PCA were searched from Pub Med,Cochrane Library,CBM,CNKI and Wan Fang Data. The inclusion RCTs were treated by data extraction and quality assessment,the meta-analysis was performed by Rev Man 5.2 software.[Results]The results of metaanalysis showed that：①invisual analog scores（VAS）：there were no significant differences in 2-hour,4-hour,8-hour,12-hour,24-hour and 48-hour scores between two groups. ②safety：the incidence rates of adverse reactions（ADRs）,including nausea,vomiting,dizziness,drowsiness,and urinary retention,in lappaconitine group were lower than those in tramadol hydrochloride group.[Conclusion]According to the existing evidences,both of tramadol hydrochloride and lappaconitine can obtain satisfactory analgesia for PCA,but the incidence rate of ADRs in lappaconitine is lower. However,due to the limitations of the included RCTs,more high-quality and large-sample RCTs are needed to confirm the reliability of this study.

关 键 词：盐酸曲马多 高乌甲素 患者自控镇痛 META分析 

分 类 号：R453[医药卫生—治疗学]