多囊卵巢综合征患者血清瘦素水平与性激素间的相关性研究  

The relationship between leptin level and hormone in patients with polycystic ovary syndrome(PCOS)

作　　者：岳峰[1] 张铁[1] 李秀莲[1] 

机构地区：[1]泰安市中心医院内分泌一科,山东省271000

出　　处：《中华临床医师杂志（电子版）》2015年第4期65-67,共3页Chinese Journal of Clinicians(Electronic Edition)

摘　　要：目的探讨多囊卵巢综合征(PCOS)患者血清瘦素(leptin)水平与性激素的相关性。方法选择初诊的PCOS患者34例作为研究对象,选择年龄及体重指数(BMI)相匹配的健康女性作为对照组进行血清瘦素、空腹血糖(FBG)、空腹胰岛素(FIn)、尿促卵泡素(FSH)、黄体生成素(LH)、孕激素(P)/雌激素(E)及睾酮(T)测定,并对它们间的相关性进行分析。结果 PCOS患者血清瘦素、LH、LH/FSH、T、BMI、FBG、胰岛素抵抗指数(HOMA-IR)水平均显著高于对照组,而FSH水平显著降低。血清瘦素水平与BMI、FBG、FIn及HOMA-IR存在相关性,进一步多元回归分析提示,血清瘦素与BMI独立相关。结论 PCOS患者血清瘦素水平变化与肥胖、糖代谢紊乱及性激素代谢异常有一定关系。Objective To evaluate the relationship between leptin level and hormone in patients with polycystic ovary syndrome （PCOS）. Methods Thirty-four patients with PCOS and 30 healthy women with matched age and body mass index （BMI） were included. After preparation of serum, the levels of leptin, fasting glucose, insulin, luteinizing hormone （LH）, follicle-stimulation hormone（FSH）, progesterone （P）, estrogen （E） and testosterone （T） were analyzed. Results PCOS patients showed significantly higher levels of serum leptin, LH, LH/FSH, T, BMI, fasting blood glucose and insulin resistance index （HOMA-IR） than control group, while the leptin levels was significantly lower in PCOS group. Spearman correlation analysis revealed that serum leptin level was related to BMI, fasting glucose, insulin and HOMA-IR. Multiple regression analysis demonstrated that serum leptin was independently related to BMI. Conclusion The improvement of leptin levels in PCOS women may related to obesity and impaired endocrinological parameters.

关 键 词：多囊卵巢综合征 瘦素 

分 类 号：R711.75[医药卫生—妇产科学]