食管鳞状细胞癌组织中Gstp和HnRNP A2/B1的表达及其临床意义  

Significance of expression of Gstp and Hn RNPA2/B1 in esophageal squamous cell carcinoma

作　　者：张艳[1] 蒲红伟[2] 谌宏鸣[3] 朱丽娟[2] 李晓梅[2] 陈晓[1] 

机构地区：[1]新疆医科大学基础医学院病理学教研室 [2]新疆医科大学厚博学院 [3]新疆医科大学基础医学院组织胚胎学教研室

出　　处：《世界华人消化杂志》2015年第1期104-109,共6页World Chinese Journal of Digestology

基　　金：国家自然科学基金资助项目;No.81360303~~

摘　　要：目的:研究食管鳞状细胞癌组织中Gstp和HnRNPA2/B1的表达及其临床意义.方法:应用免疫组织化学SP(immunohistochemical streptavidin-peroxidase)法检测68例食管鳞状细胞癌组织和48例癌旁切端正常食管组织,观察Gstp和HnRNPA2/B1的表达,并应用统计学方法分析其表达与临床病理学指标的意义.结果:(1)食管鳞状细胞癌组织中Gstp和HnRNPA2/Bl的阳性表达率分别为:60.3%(41/68)和54.4%(37/68);正常食管组织中阳性表达率分别为:27.1%(13/48)和29.1%(14/48),差异均有统计学意义(P<0.05);(2)食管鳞状细胞癌组织中Gstp在不同性别、年龄、民族、肿瘤大小及不同浸润深度组之间的表达差异无统计学意义(P>0.05);在不同分化程度、有无淋巴结转移及不同临床分期组之间的表达有差异统计学意义(P<0.05);(3)食管鳞状细胞癌组织中HnRNPA2/B1在不同性别、年龄、民族、肿瘤大小、不同浸润深度及不同临床分期组之间的表达差异无统计学意义(P>0.05);在不同分化程度、有无淋巴结转移组之间的表达差异有统计学意义(P<0.05).结论:Gstp和HnRNPA2/B1在食管鳞状细胞癌的发生和发展中可能起到一定作用;Gstp可能对食管鳞状细胞癌恶性程度判断有一定的指导意义;HnRNPA2/B1可能与食管鳞状细胞癌的发生和发展密切相关.AIM： To investigate the expression of Gstp and HnRNPA2/B1 in esophageal squamous cell carcinoma （ESCC） and to analyze their clinical significance. METHODS： Immunohistochemical method was used to detect the expression of Gstp and HnRNPA2/B1 in 68 ESCC tissues and 48 normal esophageal tissues, and their correlations with the clinicopathologic characteristics of ESCC were analyzed. RESULTS： The positive rates of Gstp and HnRNPA2/B1 expression were significantly higher in ESCC than in normal esophageal tissues （60.3% vs 27.1%, 54.4% vs 29.1%, P 〈 0.05）. Gstp expression had no significant correlation with gender, age, ethnicity, tumor size or infiltration depth （P 〉 0.05）, but was significantly correlated with tumor differentiation, lymph node metastasis and clinical stage （P 〈 0.05）. HnRNPA2/B1 expression had no significant correlation with gender, age, national, tumor size or infiltration depth （P 〉 0.05）, but was significantly correlated with tumor differentiation, lymph node metastasis and clinical stage （P 〈 0.05）. CONCLUSION： Gstp and HnRNPA2/B1 may play a role in the occurrence and development of ESCC. Gstp and HnRNPA2/B1 expression may be used to judge the malignant degree of ESCC.

关 键 词：食管鳞状细胞癌 Gstp HNRNPA2/B1 

分 类 号：R735.1[医药卫生—肿瘤]