排斥反应在同种异体气管移植物中的研究进展  

Research Progress of Immunological Rejection in Tracheal Allograft

作　　者：刘星辰 孙飞 史宏灿 

机构地区：[1]扬州大学临床医学院胸外科,江苏扬州225001

出　　处：《中国胸心血管外科临床杂志》2015年第1期71-74,共4页Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

基　　金：国家自然科学基金(81170014;81370118);江苏省"六大人才高峰"高层次人才基金(2009128);江苏省"青蓝工程"学术带头人基金(20081215)~~

摘　　要：气管的一些良性或恶性病变从理论上说是可以通过简单的手术切除,并将断端进行端端吻合来治疗的。然而这仅限于病损长度不超过成人气管长度的50%、小孩气管长度的30%。对大多患者而言,可以进行气管移植替代。然而气管移植有诸多问题有待解决,例如免疫排斥、再血管化、感染、肉芽组织增生等方面的问题。本文主要针对如何用不同的降低免疫排斥反应的方法来阐述免疫排斥反应在同种异体气管移植物领域的研究进展及应用现状。A variety of benign and malignant disorders affecting the trachea can theoretically be treated by simple resection and subsequent end-to-end anastomosis of remained trachea. Unfortunately, it is feasible only when the affected tracheal length does not exceed 50% of the entire length in adults and about 30% in children. Tracheal transplantation may be a treatment option for those patients, but still has many problems to be solved, such as immunological rejection, revascularization, infection and granulation tissue hyperplasia. This review focuses on how to use different methods to inhibit immunological rejection of tracheal transplantation, and current research progress of immunological rejection in tracheal allograft.

关 键 词：免疫排斥 气管移植 同种异体移植物 

分 类 号：R655[医药卫生—外科学]