性传播艾滋病患者抗艾滋病毒治疗后的HIV-1 pol区基因突变研究  

HIV-1 RNA pol gene mutation among patients infected with HIV through sex behaviour after antiretroviral therapy

作　　者：路新利[1] 赵宏儒[1] 王伟[1] 赵翠英[1] 白广义[1] 张玉琪[1] 李岩[1] 王莹莹[1] 陈素良[1] 

机构地区：[1]河北省疾病预防控制中心,石家庄050021

出　　处：《中国人兽共患病学报》2015年第1期53-56,69,共5页Chinese Journal of Zoonoses

基　　金：河北省医学科学研究重点课题计划(20120256)~~

摘　　要：目的分析河北省正在参加抗艾滋病毒治疗的通过性接触感染HIV者耐药性。方法采集辖区内正在接受抗艾滋病毒治疗的性接触感染HIV者的血浆,进行HIV基因型检测,分析基因突变。结果研究发现231例患者中有68例患者发生了基因突变,对抗艾滋病毒药物产生了不同程度的耐药性,耐药发生率为29.44%(68/231)。逆转录酶抑制剂的耐药发生率(29.00%,67/231)远高于蛋白酶抑制剂的耐药发生率(0.87%,2/231)。结论抗病毒药物的诱导作用是导致耐药突变的主要原因,在治疗过程中适时进行耐药监测是必要的,可为制定最佳治疗方案提供数据。In this study,we investigated the prevalence of HIV-1drug resistance among patients infected with HIV through sex behaviour who were receiving highly active anti-retroviral therapy（HAART）in Hebei Province.Plasma samples were collected from patients who were infected with HIV through sex behaviour.Then the detection of HIV-1genotype was implemented,and HIV drug-resistance mutations were analyzed.Results indicated that 68 of 231patients,infected with HIV-1by sex transmission,occurred drug-resistance mutation.The rate of the drug resistance was 29.44%（68/231）.The rate of resistance to RTs（29.00%,67/231）was much higher than that of PIs（0.87%,2/231）.Therefore,the main causation which resulted in therapic failure was drug-induced mutation.The detection of HIV drug resistance throughout HAART was useful so that we could make the better plan of highly active anti-retroviral therapy（HAART）.

关 键 词：艾滋病病毒 性接触 高效抗病毒治疗 耐药突变 

分 类 号：R511[医药卫生—内科学]