血吸虫及其相关蛋白与自身免疫性疾病(英文)  

Schistosome-induced amelioration of autoimmune diseases

作　　者：王书书[1,2,3] 计永胜[1,2] 沈继龙[1,2] 

机构地区：[1]安徽病原生物学省级实验室和人兽共患病安徽省重点实验室(安徽医科大学),合肥230032 [2]安徽医科大学免疫教研室和病原生物学教研室,合肥230032 [3]安徽医科大学附属省立医院儿内科,合肥230001

出　　处：《中国人兽共患病学报》2015年第1期57-63,共7页Chinese Journal of Zoonoses

基　　金：Funded by the National Science Foundation of China(Grant No.81171606)~~

摘　　要：自身免疫性疾病(ADs)是以特定的靶器官或多个器官系统的慢性损害和功能障碍为特征,临床上缺乏有效的治疗方法,目前发病率逐年升高,严重威胁人类健康。现有数据显示,血吸虫感染或注射血吸虫相关蛋白可能保护或减轻机体免受自身免疫性疾病的损害。研究学者已经建立相应的小鼠自身免疫疾病模型,证实了注射血吸虫蛋白具有诱导宿主Th2免疫偏移,下调Th17反应,并诱导旁路途经活化的巨噬细胞,从而减轻自身免疫性疾病,具有肯定的治疗效果。在这篇综述中,我们总结了血吸虫感染及血吸虫相关蛋白与减轻Th1介导的自身免疫性疾病之间的关系,力争明确其潜在的免疫保护机制。Autoimmune diseases（ADs）are characterized by chronic damage and dysfunction of specific target organs or multiple organ systems,which lack of effective treatment and become a severe threat to human health with its increasing incidence.Existing data show that schistosome infection or administration of schistosome proteins probably protect humans from ADs.And many researches from relevant mouse models have already proved that administration of schistosome proteins has potential therapeutic effect on ADs through alleviating inflammation by skewing host immunity to Th2 response,down-regulating Th17 reaction,and inducing alternative activation of macrophage.In this review,we sum up the relationship between Th1-mediated ADs and immunosuppression of schistosome infection in order to clarify its immunologic mechanism.

关 键 词：自身免疫性疾病 血吸虫 Th1Th2应答 

分 类 号：R383.2[医药卫生—医学寄生虫学]