妥布霉素地塞米松滴眼液治疗后部睑缘炎疗效观察  

Effects of tobramycin dexamethasone eyedrops for posterior bleparitis

作　　者：李竑[1] 曹学梅[1] 张玉枝[1] 张明明[1] 尹靓瑶[1] 

机构地区：[1]滨州市中心医院,山东省惠民县251700

出　　处：《中国实用眼科杂志》2015年第1期54-57,共4页Chinese Journal of Practical Ophthalmology

摘　　要：目的观察妥布霉素地塞米松滴眼液治疗后部睑缘炎的疗效及安全性。方法临床病例对照研究。对2012年1月至2014年1月在滨州市中心医院眼科门诊符合研究标准的后部睑缘炎患者132例，按数字法随机分为两组：试验组67例，给予妥布霉素地塞米松眼液滴眼，采用阶梯治疗：第1-3d每2h一次滴眼，之后减为每日6滴眼，持续7d，改为每日4次，以后视患者情况依次减少滴眼次数；对照组65例，给予妥布霉素眼液滴眼，滴眼频次同试验组。两组患者均辅以热敷、按摩眼睑，睡前用红霉素眼膏涂睑缘，滴人工泪液。观察治疗10、20、40d的疗效。双眼患病者，以重症眼为观察对象。计量资料应用f检验，构成比采用r检验。结果试验组与对照组治疗前的症状及体征计分差异无统计学意义（t=0．35，P〉0．05），治疗第10、20、40d试验组症状及体征明显好转（10d：t=2．12，P〈0．05；20d：t=4．44，P〈0．01；40d：f=6．76，P〈0．叭）。在治疗10d时显效率两组问虽然无差异，但有效率试验组远远高于对照组（x2=14．07P〈0．01）。治疗40d后试验组有16例治愈（23．9％），仅有3例无效（4．48％），而对照组治愈2例（3．1％），有28例无效（43．1％），差异明显具有统计学意义（r=70．27，P〈0．01）。两组眼压在治疗后不同时段与治疗前比较均无统计学意义（试验组：F=2．11，P〉O．05；对照组：F=0．11，P〉0．05）。治疗全过程无一例出现晶状体混浊。结论妥布霉素地塞米松滴眼液可明显改善后部睑缘炎患者的症状及体征，而采用阶梯式短期滴眼，可规避地塞米松易致眼压升高的风险。Objective To evaluate the effectiveness and security of Tobramycin and Dexamethasone Eyedrops for posterior blepharitis. Methods Posterior blepharitis of 132 cases from central hos- pital of Binzhou was included in this study from January 2012 to January 2014. The patients were divided into two groups, the research group used tobramycin dexamethasone eyedrops with lad- der-like treatment, that was, on the first three days, every two hours for eye drops, then six times daily for a week, subsequently four times daily, afterwards according to the conditions of patients to reduce the number of eye drops. While the patients in control group adopted tobramycin eyedrops. All patients were usually treated erythromycin ointments to eye lids at night, as well as lid hygiene with warm compresses and eyelid margin washing. The symptom, sign and side effect were recorded at the tenth day, the twentieth day, the fortieth day after treatment. Results Before treatment the difference of the symptom and sign scores of two groups had no statistically significant （t =0.35, P 〉0.05）. But after treatment the symptom and sign scores of the research group had a statistically significant decrease comparing with the scores of the control group （10th day： t =2.12, P 〈0.05; 20th day： t =4.44, P 〈0.01; 40th day： t =6.76, P 〈0.01）. The side effects of dexamethasone were mainly manifested as elevated intraocular pressure and cataract. No significant change of the intraocu- lar pressure of 132 patients at 10th day, the 20th day, 40th day after treatment when compared with before treatment （F =2.11, P 〉0.05）, and no cataract was discovered in all patients. Conclusions The tobramycin dexamethasone eyedrops can improve signs and symptoms of blepharitis patients, the method of eye drop of ladder-like treatment can avoid the danger of intraocular pressure elevation in- duced by dexamethasone.

关 键 词：妥布霉素 地塞米松 阶梯滴眼 后部睑缘炎 

分 类 号：R988.1[医药卫生—药品]