CT灌注成像对非卒中型烟雾病血流动力学的分析  

CT perfusion imaging on hemodynamic analysis of non-stroke moyamoya disease

作　　者：陈通[1] 付爱军[1] 朱军[1] 李建民[1] 宋向奇 王瑞刚[1] 牟凤群[2] 刘海霞[2] 

机构地区：[1]河北联合大学附属医院神经外科,河北唐山063000 [2]唐山工人医院

出　　处：《实用放射学杂志》2015年第1期1-4,共4页Journal of Practical Radiology

基　　金：唐山市科技局指令性课题（08130204A-1-12）。

摘　　要：目的：分析非卒中型烟雾病（MMD）患者脑血流动力学改变特点。方法对12例颅脑 CT 平扫未发现病变，经 DSA 证实的 MMD 患者（病例组）和10例正常成人（对照组）行多排螺旋 CT 灌注成像（CTPI），计算出2组样本相对应脑解剖部位血流动力学参数，对比分析所得数值的统计学意义。结果病例组不同部位脑组织各血流灌注参数差异均有显著统计学意义（P =0.000）；对照组不同部位脑组织各血流灌注参数差异均无统计学意义（P 〉0.05）。病例组额叶、颞叶、顶叶及基底节区脑血容量（rCBV）明显高于对照组（P 〈0.01）；病例组额叶脑血流量（rCBF）低于对照组（P 〈0.05）；病例组额叶、颞叶、顶叶对比剂平均通过时间（MTT）及额叶对比剂峰值时间（TTP）较对照组延长（P 〈0.05）。结论CTPI 可以定量地反映脑组织的血流动力学改变，对评价尚未出现脑组织形态学变化的 MMD 患者脑循环障碍具有重要价值。Objective To analyze characteristics of cerebral hemodynamic change of non-stroke patients with moyamoya disease. Methods Twelve cases of moyamoya disease,which were not detected in craniocerebral CT scans but confirmed by DSA （case group）,and 10 cases of normal adults （control group）were recruited and performed perfusion imaging with multiple-row spiral CT,The hemodynamic parameters of specific brain structures were calculated in the two groups.Then,statistical analysis was conducted compa-ring the parameters of the two groups.Results The perfusion parameters were significantly different between regions in case group （P=0.000）,while no significant difference was found in perfusion parameters among regions in control group（P 〉0.05）.The cerebral blood volume in frontal lobe,temporal lobe,parietal lobe and basal ganglia were significantly higher in case group than the control group （P 〈0.01）.The frontal cerebral blood flow （rCBF）in frontal lobe was lower in case group than the control group （P 〈0.05）.The average through time （determined by MTT）in frontal lobe,temporal lobe and parietal lobe,as well as time to peak（TTP）of contrast agent in frontal lobe were longer in case group （P〈.05 ）.Conclusion CT perfusion imaging can quantitatively reflect the hemodynamic changes of brain tissue and it is of great value in the evaluation of cerebral circulatory disturbance in patients with moyamoya disease whose brain morphological changes have not yet been presented.

关 键 词：CT灌注成像 烟雾病 计算机体层成像 

分 类 号：R743[医药卫生—神经病学与精神病学] R814.42[医药卫生—临床医学]