芬吗通和补佳乐在冻融胚胎移植周期中的应用比较  

Comparison of Femoston and Progynova applied in the cycle of frozen-thawed embryo transfer

作　　者：王佩玉[1] 赵军招[1] 金聪聪[1] 肖仕全[1] 林佳[1] 朱如如 

机构地区：[1]温州医科大学附属第一医院生殖医学中心,浙江温州325000

出　　处：《温州医学院学报》2015年第1期36-39,44,共5页Journal of Wenzhou Medical College

摘　　要：目的:探讨阴道塞芬吗通和口服补佳乐两种内膜准备方式对复苏囊胚移植替代周期妊娠结局的影响。方法:回顾性分析2011年7月-2012年12月在本中心接受体外受精-胚胎移植(IVF-ET)治疗的280个囊胚解冻移植的周期,其中采用阴道塞芬吗通加黄体酮替代方案107例(A组),口服补佳乐加黄体酮替代方案173例(B组),比较两种内膜准备方式对复苏囊胚移植替代周期妊娠结局的影响。结果:孕激素转化前使用雌激素的时间A组为(9.80±2.81)d,B组为(10.84±4.12)d,使用雌激素剂量A组为(15.55±10.42)mg,B组为(58.80±24.57)mg,而孕激素转化日血雌二醇(E2)水平A组为(2 955.58±1 983.94)pmol/L,B组为(923.25±441.52)pmol/L,差异均有统计学意义(均P<0.05)。每移植周期的临床妊娠率分别为57.94%(62/107)和55.49%(96/173),两者比较差异无统计学意义(P>0.05)。2组的子宫内膜厚度、优质胚胎率、移植胚胎数、胚胎种植率、临床妊娠率、流产率、多胎发生率及异位妊娠率比较差异均无统计学意义(P>0.05)。结论:在冻融胚胎移植(FET)替代周期中,与口服补佳乐比较,阴道塞芬吗通不影响妊娠结局,可以单独作为雌激素在复苏囊胚移植替代周期中应用。Objective： To compare the effect of Femoston and Progynova applied in the hormone replace-ment cycle for frozen-thawed blastocyst transfer.Methods： Two hundred and eight blastocyst FET cycles were analyzed retrospectively from July 2011 to December 2012. All cases were divided into two groups： 107 Femo-ston plus progesterone protocol group （group A）, 173 Progynova plus progesterone protocol group （group B）. Patient’s age, basic endocrine, endometrial thickness on the day of progesterone initiation, mean dosage and dura-tion of estrogen per cycle, high quality embryo rate, mean number of embryo transferred per patient, implantation rate, clinical pregnancy rate, early abortion rate and ectopic pregnancy rate were compared between the two groups. Results： Before progesterone initiation, the duration of estrogen used in group A and group B was （9.80±2.81） d and （10.84±4.12） d and the dosage of estrogen used in group A and B was （15.55±10.42） mg and （58.80±24.57） mg respectively. The estradiol level on the day of progesterone initiation in group A and group B was （2 955.58± 1 983.94） pmol/L and （923.25±441.52） pmol/L, respectively. They all had signiifcant differences （P〈0.05）. Clinical pregnancy rate were 57.94% （62/107） and 55.49% （96/173）, respectively, and there was no statistically signiifcant difference （P〉0.05）. Patient’s endometrial thickness on the day of progesterone initiation, high quality embryo rate, mean number of embryo transferred for per patient, implantation rate, clinical pregnancy rate, early abortion rate and ectopic pregnancy rate in these two groups had no signiifcant different （P〈0.05）.Conclusion： In hormone replacement cycle for frozen-thawed embryo transfer, the use of Femoston can obtain the similar pregnancy rate compared with Progynova. So Femoston can be used as estrogen alone in blastocyst transplant recovery cycle.

关 键 词：冻融囊胚移植 替代周期 芬吗通 内膜准备 妊娠 

分 类 号：R715[医药卫生—妇产科学]