唑来膦酸对骨质疏松骨含量的影响  

Effect of zoledronic acid on bone mass in osteoporotic patients

作　　者：高雷[1] 任艳[1] 高华增[1] 

机构地区：[1]吉林省人民医院创伤骨科,长春130021

出　　处：《中国骨质疏松杂志》2015年第1期72-74,共3页Chinese Journal of Osteoporosis

摘　　要：目的探讨双膦酸盐对骨质疏松骨量的影响。方法选绝经后骨质疏松症患者59例,随机分为治疗组和对照组,其中治疗组（30例）,一次性静脉滴注唑来膦酸注射液5 mg,后次日始日一次静点0.9%生理盐水100 ml＋葡萄糖酸钙10 ml（1g）3--5天,同时碳酸钙600 mg/d,活性维生素D3 400IU/d口服;对照组（29例）,给予同剂量的碳酸钙及活性维生素D3口服,6个月后复查评价疗效。结果患者临床疗效比较,治疗后患者BMD值有不同程度增高,其中骨含量一项升高明显,疼痛感明显下降,与治疗前比较,差异有统计学意义（P〈0.05）,随访期间无一例骨质疏松性骨折发生。结论双膦膦酸联合钙剂治疗绝经后骨质疏松,能显著改善患者的疼痛症状,有效的改善及维持BMD水平,增加骨量降低了骨质疏松骨折的发生率。是治疗绝经后骨质疏松症的安全有效方法。Objective To explore the influence of bisphosphonates in bone mass in osteoporosis.Me thods Fifty-nine patients with postmenopausal osteoporosis were selected and were randomly divided into treatment group（ n = 30） and control group（ n =29）.In treatment group,patients received intravenous 5mg zoledronic acid（ Aclasta） injection once,and continued with 0.9%normal saline 100 ml and calcium gluconate 10 ml（ 1g） once a day for 3- 5 days.They also took calcium carbonate 600 mg / d and active vitamin D3 400 iu / d.In control group,patients were given oral calcium 600 mg / d and active vitamin D3 400 iu / d.The efficacy was evaluated after 6 months.Re sults After the treatment,BM D of patients increased in varying degree.Bone mineral content was elevated significantly.The pain decreased significantly.The difference was statistically significant（ P〈0.05）compared with that before treatment.No osteoporotic fractures occurred during the follow-up.Conclusion Bisphosphonates combining with calcium can significantly relieve the pain symptom,improve and maintain the BM D level,increase bone mass and reduce the incidence of osteoporotic fractures in the treatment of postmenopausal osteoporosis.It is a safe and effective method for treatment of postmenopausal osteoporosis.

关 键 词：密固达 骨密度 骨量 钙剂 活性维生素D 骨质疏松骨折 

分 类 号：R68[医药卫生—骨科学]