牙周炎对慢性细菌性前列腺炎大鼠前列腺的影响  

Effect of periodontitis on rats with chronic bacterial prostatitis

作　　者：刘城城[1] 韩广玮[1] 陈江川[1] 易善红[1] 冯小倩[2] 

机构地区：[1]第三军医大学新桥医院泌尿外科,重庆400037 [2]第三军医大学新桥医院口腔科,重庆400037

出　　处：《局解手术学杂志》2015年第1期6-10,共5页Journal of Regional Anatomy and Operative Surgery

摘　　要：目的研究牙周炎对慢性细菌性前列腺炎大鼠前列腺的影响。方法 80只SD大鼠随机分为4周组及8周组,每组40只,再将4周组和8周组分别随机分为空白对照组(N组)、慢性细菌性前列腺炎组(CBP组)、牙周炎组(PE组)和慢性细菌性前列腺炎合并牙周炎组(CBP+PE组),每组各10只。观察比较大鼠前列腺组织病理形态学改变、炎症评分、TNF-α、IL-1β的含量及牙周各项指标。结果在4周组中,PE组、CBP+PE组牙周各项指标高于N组、CBP组(P<0.05),而PE组与CBP+PE组之间以及N组与CBP组之间牙周各项指标无明显差异(P>0.05);CBP+PE组和CBP组前列腺组织病理、炎症评分、TNF-α、IL-1β比N组和PE组均高(P<0.05),而N组与PE组之间以及CBP+PE组与CBP组之间前列腺组织病理、炎症评分、TNF-α、IL-1β无明显差异(P>0.05)。在8周组中PE组、CBP+PE组牙周各项指标高于N组和CBP组(P<0.05),而PE组与CBP+PE组之间以及N组与CBP组之间牙周各项指标无明显差异(P>0.05);CBP+PE组、CBP组前列腺组织病理、炎症评分、TNF-α、IL-1β较N组、PE组高(P<0.05),而N组与PE组之间前列腺组织病理、炎症评分、TNF-α、IL-1β无明显差异(P>0.05),CBP+PE组前列腺组织病理、炎症评分、TNF-α、IL-1β则较CBP组高(P<0.05)。4周组和8周组比较,N组各项观察指标无明显差异;8周PE组牙周各项指标高于4周PE组(P<0.05),前列腺组织病理、炎症评分、TNF-α、IL-1β无明显差异(P>0.05);8周CBP组前列腺组织病理、炎症评分、TNF-α、IL-1β较4周CBP组降低(P<0.05),而牙周各项指标无明显差异(P>0.05);8周CBP+PE组与4周CBP+PE组比较前列腺组织病理、炎症评分、TNF-α、IL-1β较低(P<0.05),但8周CBP+PE组牙周各项指标较4周组高(P<0.05)。结论慢性细菌性前列腺炎较长时间合并牙周炎,在大鼠模型上能抑制大鼠慢性细菌性前列腺炎的自愈倾向使其保持在慢性炎症阶段。Objective To study the effect of periodontitis on rats with chronic bacterial prostatitis. Methods A total of 80 male rats were randomly divided into the 4 weeks group （n=40） and the 8 weeks group （n=40）, and then the two groups were randomly divided into the normal control group （N=10）, the periodontitis group （PE=10）, the chronic bacterial prostatitis group （CBP=10）, and the peri-odontitis＋chronic bacterial prostatitis group （CBP＋PE=10） respectively. The pathological changes, inflammation score, level of TNF-αand IL-1β, and indicators of periodontal of all rats were observed. Results In the 4 weeks group, the indicators of periodontal in PE group＆amp;nbsp;and CBP＋PE group were higher than that in N group and CBP group （P〈0. 05）, but there was no significant difference between PE group and CBP＋PE group as well as between the N group and the CBP group （P〉0. 05）. The pathological changes, inflammation score,TNF-αlevel ,IL-1 β level in CBP＋PE group and CBP group were higher than that in N group and PE group （P〈0. 05）, while there was no sing-nificant difference between N group and PE group as well as between CBP＋PE group and CBP group （P〉0. 05）. In the 8 weeks group, the indicators of periodontal in PE group and CBP＋PE group were higher than that in N group and CBP group （P〈0. 05）, but there was no sig-nificant difference between PE group and CBP＋PE group as well as between the N group and the CBP group （P〉0. 05）. The pathological changes, inflammation score, TNF-α level , IL-1 β level in CBP ＋PE group and CBP group were higher than that in N group and PE group （P〈0. 05）,while there was no singnificant difference between N group and PE group （P〉0. 05）. The pathological changes, inflam-mation score,TNF-α level ,IL-1 β level in CBP＋PE group were higher than those in the CBP group （P〈0. 05）. Compared between 4 weeks group and 8 weeks group, there was no obvious difference in N group in terms of periodontal index

关 键 词：牙周炎 慢性细菌性前列腺炎 病理 炎症评分 TNF-Α IL-1Β 

分 类 号：R697.33[医药卫生—泌尿科学] R781.42[医药卫生—外科学]