N-phosphoryl amino acid models for P–N bonds in prebiotic chemical evolution  

作　　者：Feng Ni Chuan Fu Xiang Gao Yan Liu Pengxiang Xu Liu Liu Ye Lv Songsen Fu Ying Sun Daxiong Han Yan-Mei Li Yufen Zhao 

机构地区：[1]Department of Chemistry and Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University [2]Department of Chemistry, University of Southern California [3]School of Pharmaceutical Science, Xiamen University [4]Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Ministry of Education [5]Department of Chemistry,Tsinghua University

出　　处：《Science China Chemistry》2015年第3期374-382,共9页中国科学（化学英文版）

基　　金：supported by the National Basic Research Program of China(2013CB910700,2012CB821600);the National Natural Science Foundation of China(21232005,21375113,21305115);the Program of Chinese Ministry of Education for Changjiang Scholars and Innovative Research Team in University

摘　　要：Post-translational modification of proteins by N-phosphorylation of the basic amino acid residues plays important roles in biological processes. The high-energy P–N bond might have contributed to the evolution of prebiotic chemistry. N-phosphoryl amino acids(PAAs) can serve as interesting small molecular models for the study of P–N bonds in prebiotic chemical evolution. PAAs are capable of simultaneously producing several important biomolecules such as polypeptides and oligonucleotides under mild reaction conditions. In this review, we describe the chemistry of PAAs, discusse their likely prebiotic origins and their reactivity and how they relate to biological P–N bond species. We also depict a possible prebiotic scenario mediated by PAAs in which PAAs may have acted as one of the essential forces driving prebiotic biomolecules to the first protocell.Post-translational modification of proteins by N-phosphorylation of the basic amino acid residues plays important roles in biological processes. The high-energy P–N bond might have contributed to the evolution of prebiotic chemistry. N-phosphoryl amino acids（PAAs） can serve as interesting small molecular models for the study of P–N bonds in prebiotic chemical evolution. PAAs are capable of simultaneously producing several important biomolecules such as polypeptides and oligonucleotides under mild reaction conditions. In this review, we describe the chemistry of PAAs, discusse their likely prebiotic origins and their reactivity and how they relate to biological P–N bond species. We also depict a possible prebiotic scenario mediated by PAAs in which PAAs may have acted as one of the essential forces driving prebiotic biomolecules to the first protocell.

关 键 词：N-phosphoryl amino acid biological P–N bond chemical evolution origin of life 

分 类 号：Q517[生物学—生物化学]