泼尼松治疗原发性肾病综合征的临床不良反应分析  

Clinical Analysis of Adverse Drug Reaction of Prednisone on Primary Nephritic Syndrome

作　　者：孟冬梅[1] 喻鹏久[1] 邓礼荷[2] 陈文瑛[1] 黄珊珊[1] 肖翔林[1] 

机构地区：[1]广州医科大学附属第一医院,药学部,广东广州510120 [2]肇庆医学高等专科学校,药学系,广东肇庆526020

出　　处：《今日药学》2015年第1期35-36,43,共3页Pharmacy Today

基　　金：广州市卫生局医药卫生科技项目(201102A213140)

摘　　要：目的分析应用泼尼松治疗原发性肾病综合征(PNS)过程中引起的不良反应。方法对使用泼尼松治疗PNS过程中发生不良反应的患者进行研究,并分析PNS复发的影响因素。结果在使用泼尼松治疗PNS过程中50例患者出现69例次不良反应,主要包括感染23例(33.3%)、撤药综合征14例(20.3%)、类固醇性糖尿病13例(18.8%)等。并且PNS复发与病理类型、撤药综合征、感染、劳累有一定相关性。结论 PNS患者的不良反应中感染的比率相对较高,不良反应中撤药综合征、感染是PNS患者复发的主要原因,注意不良反应的防治可以减少复发。OBJECTIVE To analyze the adverse drug reactions of prednisone in treatment of primary nephritic syndrome（ PNS）.METHODS The PNS patients treated with prednisone were followed up to investigate the incidence of adverse drug reactions,and the influence factors of PNS remission were studied. RESULTS Among the PNS patients treated with prednisone,adverse drug reactions were observed in 50 patients,69 cases of adverse drug reactions occurred,including 23 cases of infectious diseases（ 33.3%）,14 cases of withdrawal syndrome（ 20. 3%）,13 cases of steroid diabetes（ 18. 8%） mainly. Recurrence of PNS had certain correlation with pathological type,withdrawal syndrome,infection and fatigue. CONCLUSION The incidence of infection was relatively high in the adverse drug reactions of PNS patients. Adverse drug reactions of withdrawal syndrome and infectious diseases were the principal causes of PNS recurrence,pay attention to the prevention of the adverse drug reactions can reduce the recurrence.

关 键 词：泼尼松 原发性肾病综合征 不良反应 

分 类 号：R97[医药卫生—药品]