促性腺激素释放激素类似物对中枢性性早熟女童体重指数的影响  

Influence on Body Mass Index-Standard Deviation Scores of Girls with Central Precocious Puberty after Gonadotropin-Releasing Hormone Analog Treatment

作　　者：陈彩云[1] 程志宏[1] 董雪[1] 

机构地区：[1]珠海市妇幼保健院,广东珠海519000

出　　处：《今日药学》2015年第1期51-52,58,共3页Pharmacy Today

摘　　要：目的评价中枢性性早熟（CPP）女童使用促性腺激素释放激素类似物（GnRHa）后体重的变化。方法回顾性收集2005~2013在本院治疗并进行随访的CPP女童。比较治疗前、治疗6个月、治疗12个月及治疗结束后6个月的体重指数标准差积分（BMI-SDS）。结果 32名CPP女童纳入研究,其中超重12例,体重正常20例,治疗前后BMI-SDS有上升趋势,但是无统计学意义（P〉0.05）。结论 GnRHa治疗CPP会出现BMI波动,但符合正常儿童发育趋势。OBJECTIVE To evaluate the changes in body weight of girls with central precocious puberty（ CPP）,who were administered with gonadotropin-releasing hormone analog（ GnRHa）. METHODS Girls with CPP and administered monthly with GnRHa at Zhuhai Maternity and Child Health Hospital in 2005- 2013 were included. The body mass index-standard deviation scores（ BMI-SDS） were compared before treatment,6th month treatment,12 th month treatment and 6 months after treatment. RESULTS All of the 32 girls with CPP included in this study,12 of them were overweight. BMI-SDS was on the up trend after treatment without statistical significance（ P0.05）. CONCLUSION BMI of girls with CPP was fluctuating in normal development trend after GnRHa treatment.

关 键 词：促性腺激素释放激素类似物 中枢性性早熟 体重指数 不良反应 

分 类 号：R97[医药卫生—药品]