正交试验优选归藤通管灌肠剂水提取工艺  

Optimization of Water Extraction for Guiteng Tongguan Enema by Orthogonal Test

作　　者：王红丽[1] 唐进法[1] 卫爱武[1] 翟海容 程伟[2] 康冰亚[1] 

机构地区：[1]河南中医学院第一附属医院,河南郑州450000 [2]河南中医学院,河南郑州450046

出　　处：《中国现代中药》2015年第2期164-166,共3页Modern Chinese Medicine

摘　　要：目的:优选归藤通管灌肠剂水提取工艺。方法:以绿原酸为指标,采用HPLC测定其含量,选取加水倍数、煎煮时间、煎煮次数为考察因素,采用正交试验法优选归藤通管灌肠剂水煎煮工艺。结果:最佳提取工艺为加6倍量水,煎煮2次,每次1.5 h。结论:优选的水提取工艺稳定、合理,可为归藤通管灌肠剂的制剂生产提供参考。Objective： To optimize boiling water extraction of Guiteng Tongguan Enema. Methods： With the content of ehlorogenie acid as index, orthogonal test was used to optimized boilingwater extraetionof Guiteng Tongguan Enema with the amount of water, extraction time and times as factors. Results： Optimal extraction was as follows： sixfold amount of water, extract 2 times with 1.5 hours per time. Conclusion： Optimized extraction method is reasonable and feasible, it could be applied in mass production of Guiteng Tong^uan Enema.

关 键 词：归藤通管灌肠剂 绿原酸 正交试验 高效液相色谱法 

分 类 号：R284.2[医药卫生—中药学]