霍奇金淋巴瘤并噬血细胞综合征1例报告  

Hodgkin lymphoma complicated with hemophagocytic lymphohistiocytosis: A case report

作　　者：周颖[1] 赵瑜[1] 陆晓林[1] 刘婷[1] 于力[1] 

机构地区：[1]解放军总医院血液科,北京100853

出　　处：《解放军医学院学报》2015年第1期83-85,共3页Academic Journal of Chinese PLA Medical School

基　　金：卫生行业科研专项项目(201202017)~~

摘　　要：目的报告1例合并噬血细胞综合征的霍奇金淋巴瘤病例。方法以持续高热起病的1例初治霍奇金淋巴瘤,抗感染治疗效果不佳,予ABVD(表柔比星、博来霉素、长春瑞滨、达卡巴嗪)方案化疗后体温一度控制,后又出现高热,伴进行性全血细胞减少及肝功能恶化,完善相关检查后诊断明确为合并噬血细胞综合征,加予肾上腺糖皮质激素。结果患者噬血得到有效控制,相关指标均恢复正常。结论霍奇金淋巴瘤合并噬血细胞综合征十分少见且预后不佳,其最佳治疗方案有待于进一步探索。Objective To describe the symptom of a man diagnosed with mixed-cellularity Hodgkin lymphoma（HL） complicated with hemophagocytic lymphohistiocytosis（HLH）. Methods The patient presented with high fever, pancytopenia and jaundice. His fever was completely unresponsive to broad-spectrum antibiotics and then he was given steroid and ABVD（doxorubicin, bleomycin, vinblastine, dacarbazine） treatment. After treatment, his temperature was controlled temporarily while then raised high again with pancytopenia and deterioration of liver function. After a series of laboratory examination, he was diagnosed as HLH and given glucocorticoid. Results The disease was controlled temporarily and the related indexes were back to normal. Conclusion The present case is very rare with poor prognosis. Large scale studies are warranted to confirm the optimal treatment strategies.

关 键 词：霍奇金淋巴瘤 噬血细胞综合征 混合细胞型 治疗 

分 类 号：R55[医药卫生—血液循环系统疾病]