Prevention of Postoperative Tendon Adhesion by Biodegradable Electrospun Membrane of Poly(lactide-co-glycolide)  

作　　者：Zhi-ming Song Bo Shi 丁建勋 Xiu-li Zhuang Xiao-nan Zhang 付长峰 Xue-si Chen 

机构地区：[1]Department of Sports Medicine,First Hospital of Jilin University [2]Key Laboratory of Polymer Ecomaterials,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences [3]Department of Spine Surgery,First Hospital of Jilin University [4]Changchun Sino Biomaterials Co.,Ltd.

出　　处：《Chinese Journal of Polymer Science》2015年第4期587-596,共10页高分子科学（英文版）

基　　金：financially supported by the National Natural Science Foundation of China(Nos.51303174,51321062,51233004,51390484,51273196,and 51203153);the Scientific Development Program of Jilin Province(No.20140520050JH)

摘　　要：An electrospun poly（lactide-co-glycolide） （PLGA） membrane was prepared and used to perform the anti-adhesion of Achilles tendon. Throughout the experiments, the membrane showed an appropriate degradation rate, and the pH values of degradation media were maintained at around 7.4. Simultaneously, the excellent biocompatibility of the membrane in vitro and in vivo was confirmed by live/dead and histopathological analyses. Meanwhile, the membrane can reduce tendon adhesion significantly and promote functional recovery effectively. The encouraging results were further demonstrated by hematoxylin and eosin （H＆E）, and Masson＇s trichrome stainings, and type I collagen immunohistochemical analysis. It was concluded that the model treated with the electrospun PLGA membrane was significantly better with respect to the adhesion prevention and tissue repair than that without treatment. Considering the results of degradation and adhesion prevention efficacy, the electrospun PLGA membrane would be a great candidate for the prevention of postoperative tendon adhesion.An electrospun poly（lactide-co-glycolide） （PLGA） membrane was prepared and used to perform the anti-adhesion of Achilles tendon. Throughout the experiments, the membrane showed an appropriate degradation rate, and the pH values of degradation media were maintained at around 7.4. Simultaneously, the excellent biocompatibility of the membrane in vitro and in vivo was confirmed by live/dead and histopathological analyses. Meanwhile, the membrane can reduce tendon adhesion significantly and promote functional recovery effectively. The encouraging results were further demonstrated by hematoxylin and eosin （H＆E）, and Masson＇s trichrome stainings, and type I collagen immunohistochemical analysis. It was concluded that the model treated with the electrospun PLGA membrane was significantly better with respect to the adhesion prevention and tissue repair than that without treatment. Considering the results of degradation and adhesion prevention efficacy, the electrospun PLGA membrane would be a great candidate for the prevention of postoperative tendon adhesion.

关 键 词：ANTI-ADHESION Achilles tendon repair BIODEGRADABILITY Electrospun membrane Poly（lactide-co-glycolide）. 

分 类 号：TQ342.87[化学工程—化纤工业]