注射用五水头孢唑林钠与钠钾镁钙葡萄糖注射液的配伍稳定性  

Compatible stability of cefazolin sodium with sodium potassium magnesium calcium in glucose injection

作　　者：杨静[1] 刘自玲[2] 杨建[2] 李军沂 

机构地区：[1]江苏省连云港市妇幼保健院药事科,连云港222006 [2]江苏恒瑞医药股份有限公司,连云港222047

出　　处：《世界临床药物》2015年第2期113-116,共4页World Clinical Drug

基　　金：连云港市科技局科技项目(SH1227)

摘　　要：目的考察注射用五水头孢唑林钠与钠钾镁钙葡萄糖注射液的配伍稳定性。方法观察室温下8 h内配伍液的外观、p H和不溶性微粒。采用高效液相色谱法测定配伍液分别在0℃和35℃环境避光与光照条件下头孢唑林钠的含量和杂质变化。结果室温下配伍液8 h内外观、p H和不溶性微粒均无明显变化。0℃光照和避光与35℃光照和避光四种条件下,8 h内配伍液中的头孢唑林钠含量和杂质均符合标准规定。结论注射用五水头孢唑林钠与钠钾镁钙葡萄糖注射液临床可配伍使用,建议8 h内输注完毕。Objective To study the compatible stability of cefazolin sodium with sodium potassium magnesium calcium in glucose injection. Methods The appearance of mixed solution was observed. And its pH and particle matter within 8 hours in room temperature were tested. HPLC method was designed to study the change of contents of cefazolin sodium and impurities in 0~C, 35 ~C, light and light-avoided conditions. Results No significant differences were found in the appearance, the pH value and the particle matter within 8 hours at room temperature. All the contents of cefazolin sodium and impurities under varied conditions were conformed to the standard of Chinese Pharmacopeia. Conclusion Cefazolin sodium for injection can be mixed with sodium potassium magnesium calcium and glucose injection for clinical use within 8h.

关 键 词：头孢唑林钠 钠钾镁钙葡萄糖注射液 配伍稳定性 

分 类 号：R978[医药卫生—药品] R927.11[医药卫生—药学]