乌司他丁和常规方法治疗重症脓毒血症疗效对比观察  

Comparative observation of curative effects by ulinastatin and conventional method in the treatment of severe sepsis

作　　者：陈文标[1] 彭思苹 陈玉兰[1] 江美嫦 关健明[1] 

机构地区：[1]广东省佛山市南海区第六人民医院,528248

出　　处：《中国现代药物应用》2015年第7期1-3,共3页Chinese Journal of Modern Drug Application

摘　　要：目的探讨分析乌司他丁和常规方法在重症脓毒血症患者治疗过程中的不同临床疗效。方法 50例重症脓毒血症患者,将其随机分为观察组和对照组,各25例。其中对照组患者接受常规方法治疗,观察组在对照组的基础上联合采用乌司他丁进行治疗。对比分析两组患者的临床疗效,并实时监测观察两组患者细胞因子的具体变化情况。结果对照组患者12例死亡,病死率为48.00%,康复率为16.00%(4/25);观察组患者5例死亡,病死率为20.00%,康复率为40.00%(10/25)。接受治疗后,两组患者的肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)均呈现出明显的下降情况,而观察组下降的幅度明显大于对照组,比较差异具有统计学意义(P<0.05);两组患者的白细胞介素-10(IL-10)在治疗后均出现了上升情况,而观察组上升的幅度明显大于对照组,比较差异具有统计学意义(P<0.05)。结论在重症脓毒血症的临床诊治研究中,常规治疗方法联合乌司他丁,疗效显著,安全高效,在显著降低患者病死率的同时,减轻了患者的痛苦,帮助患者早日康复,值得在临床上应用和推广。Objective To investigate and analyze the different clinical effects by ulinastatin and conventional method in the treatment of severe sepsis. Methods A total of 50 patients with severe sepsis were randomly divided into observation group and control group, with 25 cases in each group. The control group received conventional method for treatment, and the observation group received additional ulinastatin for combined treatment. Clinical effects of the two groups were compared and analyzed, and their change conditions of cytokines were under real-time monitoring. Results The control group had mortality as 48.00% as 12 death cases, and its recovery rate was 16.00%（4/25）. The observation group had mortality as 20.00% as 5 death cases, and its recovery rate was 40.00%（10/25）. After treatment, obvious decrease was found in indexes of tumor necrosis factor-α（TNF-α）, interleukin-6（IL-6）, and interleukin-8（IL-8） of the two groups. The observation group had larger decrease than the control group, and the difference had statistical significance（P〈0.05）. Both groups had increased in interleukin-10（IL-10） after treatment, and the observation had larger increase than the control group. Their difference had statistical significance（P〈0.05）. Conclusion Combination of conventional method and ulinastatin in the clinical treatment of severe sepsis provides precise effect and high safety. It can relieve patients＇ pain while remarkably reducing their mortality. It promotes early recovery in patients, and is worthy of clinical promotion and application.

关 键 词：乌司他丁 细胞因子 重症脓毒血症 

分 类 号：R459.7[医药卫生—急诊医学]