垫状卷柏中一个新的炔酚类衍生物(英文)  

A new selaginellin derivative from Selaginella pulvinata

作　　者：曹园[1,2] 吴永平[3] 段金廒[1] 

机构地区：[1]南京中医药大学,江苏省中药资源产业化过程协同创新中心/中药资源产业化与方剂创新药物国家地方联合工程研究中心,江苏南京210023 [2]南京中医药大学附属医院,江苏南京210036 [3]江苏省药物研究所,江苏南京210009

出　　处：《药学学报》2015年第2期199-202,共4页Acta Pharmaceutica Sinica

基　　金：Project supported by the National Natural Science Foundation of China(81102772);Jiangsu Planned Projects for Postdoctoral Research Funds(1302083B)

摘　　要：采用硅胶、Sephadex LH-20等多种材料进行分离纯化,通过理化方法和波谱分析进行结构鉴定,从垫状卷柏全草中分离并鉴定了两个炔酚类衍生物,分别为selaginellin S(1)和M(2)。其中,化合物1为新炔酚类衍生物,是炔酚类成分生源合成途径的关键前体物质;通过ECD计算确定了其绝对构型。化合物2为首次从该植物中报道。A new selaginellin derivative named as selaginellin S（1） was isolated from the whole plants of Selaginella pulvinata（Hook. et Grev.） Maxim.（Selaginellaceae）, together with a known one（selaginellin M, 2）. Compounds 1 and 2 were separated and purified by silica gel and Sephadex LH-20 column chromatography. Their structures were determined on the basis of extensive spectroscopic analysis including IR, MS, 1D and 2D NMR experiments, as well as ECD calculations. Compound 1 is a key intermidiant in the biosynthesis pathway of selaginellins. Compound 2 is first reported in this plant.

关 键 词：垫状卷柏 炔酚衍生物 selaginellin S 

分 类 号：R284[医药卫生—中药学]