海洋来源真菌Penicillium citrinum中的一个新桔霉素衍生物(英文)  

A novel citrinin derivative from the marine-source fungus Penicillium citrinum

作　　者：倪敏[1] 林伟铃[1] 杨鹏[2] 毛水春[2] 

机构地区：[1]福建卫生职业技术学院,福建福州350101 [2]南昌大学药学院,江西南昌330006

出　　处：《药学学报》2015年第2期203-206,共4页Acta Pharmaceutica Sinica

基　　金：Project supported by the Scientific Research Foundation of Fujian Health Department(2010-2-45);the Scientific Research Foundation of Fujian Education Department(JB13323)

摘　　要：从一株海洋来源真菌Penicillium citrinum中分离得到了一个结构新颖的桔霉素衍生物penicitrinol L(1)以及两个已知类似物penidicitrinin B(2)和pennicitrinone A(3)。通过一维和二维核磁以及高分辨质谱等波谱学方法确定了新化合物的结构。此外,化合物1对人白血病HL-60细胞具有中等的抑制活性,化合物3对人黑色素瘤A375细胞具有较弱的抑制活性。A novel citrinin derivative, penicitrinol L（1）, along with two known analogues, penidicitrinin B（2） and pennicitrinone A（3） were isolated from the marine-source fungus Penicillium citrinum. The structure of the new compound was elucidated by spectroscopic methods including one and two-dimensional NMR as well as high-resolution mass spectrometric analysis. Furthermore, compound 1 showed modest cytotoxic activity against HL-60 cell line and compound 3 showed weak cytotoxic activity against A375 cell line.

关 键 词：桔霉素衍生物 海洋真菌 次级代谢物 细胞毒活性 

分 类 号：R284.2[医药卫生—中药学]