骨关节炎严重程度与血清IL-4和sIL-4R水平的相关性研究  

Correlation between the severity of osteoarthritis and the serum levels of IL-4 and sIL-4R

作　　者：陈文革[1] 杨朝晖[1] 刘清高[1] 鄢含坤 

机构地区：[1]湖北民族学院附属民大医院骨科,湖北恩施445000

出　　处：《解放军医学杂志》2015年第1期63-65,共3页Medical Journal of Chinese People's Liberation Army

摘　　要：目的探讨骨关节炎严重程度与血清白介素4(IL-4)和人可溶性IL-4受体(s IL-4R)的相关性。方法选择2011年5月-2013年5月收治的50例骨关节炎患者(观察组),另选择同期50例健康体检者(对照组),采用ELISA法检测两组血清IL-4和s IL-4R水平并进行组间比较。采用K&L评级法和WOMAC骨关节炎指数评价观察组患者骨关节炎严重程度,并分析其与血清IL-4和s IL-4R水平的关系。结果观察组血清s IL-4R水平(82.12±11.24ng/ml)显著高于对照组(30.67±5.23ng/ml),差异有统计学意义(P<0.05),但两组血清IL-4水平(分别为14.39±7.14、15.23±6.28ng/L)比较差异无统计学意义(P>0.05)。观察组患者血清s IL-4R水平与WOMAC指数呈正相关(r=0.313,P<0.05);随K&L分级增加,血清s IL-4R水平逐渐递增,各分级比较差异有统计学意义(P<0.05)。结论血清s IL-4R水平与骨关节炎严重程度相关,临床可以将其作为评估骨关节炎严重程度的指标。Objective To explore the correlation between the severity of osteoarthritis and the serum levels ofinterleukin-4 （IL-4） and soluble IL-4 receptor （sIL-4R）. Methods Fifty patients with osteoarthritis hospitalized from May 2011 to May 2013 were selected as study group, and 50 healthy individuals during the corresponding period were selected as control group. The serum levels of IL-4 and sIL-4R were determined by EILISA and compared between the two groups. The severity of osteoarthritis of patients in the study group was assessed by Kellgren and Lawrence （K＆L） grading system and Western Ontario and McMaster Universities Osteoarthritis Index （WOMAC）. The relationship between both K＆L grade and WOMAC scores and the serum levels of IL-4 and sIL-4R was analyzed. Results The serum level of sIL-4R in the study group （82.12 ± 11.24ng/ml） was significantly higher than that in control group （30.67±5.23ng/ml, P〈0.05）, but the levels of IL-4 in two groups were similar （14.39 ±7.14 and 15.23±6.28ng/L, P〉0.05）. The serum level of sIL-4R in the study group was positively correlated with the WOMAC scores （r=0.313, P〈0.05）. The sIL-4R levels were increased gradually along with the increase in K＆L grade, and the difference between different grades was significant （P〈0.05）. Conclusion The serum level of sIL-4R is correlated with the severity of osteoarthritis, and may be used as an evaluation indicator of severity of osteoarthritis.

关 键 词：骨关节炎 白细胞介素4 受体 白细胞介素4 

分 类 号：R684.3[医药卫生—骨科学]