记忆性CD8＋T细胞免疫应答机制  

Mechanism of Immune Response of Memory CD8＋T Cells

作　　者：于慧杰[1] 吕进[1] 宋秀军[1] 贾洪琳[2] 江其生[1] 

机构地区：[1]中国人民解放军第二炮兵总医院中心实验室,北京市100088 [2]中国人民解放军第二炮兵总医院肝胆外科,北京市100088

出　　处：《医学分子生物学杂志》2015年第1期26-29,共4页Journal of Medical Molecular Biology

基　　金：国家自然科学基金（No.81172130）

摘　　要：免疫记忆是高等脊椎动物获得性免疫应答的显著特征。体液免疫应答与细胞免疫应答构成免疫记忆的两大重要分支。免疫记忆是指机体在对某一抗原产生特异性识别及应答的同时，记住该抗原，当再次遭遇同一抗原时，能发生快速和强烈的免疫应答。记忆性T细胞与感染免疫、肿瘤免疫、疫苗设计、自身免疫性疾病和移植排反应都有着密切的关系，深入研究记忆性T细胞的生成、维持、功能和调控机制不仅能指导新型疫苗的设计，有望更好的治疗疾病。Immune memory is a predominant feature of adoptive immune response of higher ver- tebrates. Humoral immune response and cellullar immunologic response are two important branches in immunologic memory. Immunological memory is the ability of the body to remember the antigen when it initially specifically recognizes and responds to the antigen and then make a rapid and in- tense immune response to the antigen encountered again. Memory T cells are related to infection, tumor immunity, design of vaccines, autoimmunity disease and transplantation rejec- tion. Understanding the generation, maintenance, function and regulatory mechanism of memory T cells will help design vaccines and provide a promising immunotherapy for diseases.

关 键 词：记忆性CD8+T细胞:免疫记忆 MICRORNA 

分 类 号：R392.12[医药卫生—免疫学]