人免疫缺陷病毒阳性人群人乳头状瘤病毒感染的型别分析  

Genotyping of human papillomavirus among human immunodeficiency virus-positive populations

作　　者：吴焱[1] 王鹏[2] 魏春波[1] 张亮[2] 闫会文[1] 伦文辉[1] 李兴旺[3] 

机构地区：[1] 首都医科大学附属北京地坛医院皮肤性病科,北京100015 [2] 首都医科大学附属北京地坛医院病理科,北京100015 [3] 首都医科大学附属北京地坛医院感染科,北京100015

出　　处：《中华皮肤科杂志》2015年第2期76-79,共4页Chinese Journal of Dermatology

摘　　要：目的 了解人免疫缺陷病毒（HIV）阳性人群人乳头状瘤病毒（HPV）感染状况、型别分布特征及与HIV阴性人群的差异.方法 选择门诊患有尖锐湿疣或主诉近期与可疑尖锐湿疣患者有性接触者作为研究对象,包括HIV阳性组62例和HIV阴性组2 716例,采用基因芯片技术对外生殖器部位皮肤黏膜样本进行HPV检测,采用SPSS 19.0统计软件进行x2检验.结果 HIV阳性组中,HPV总感染率74.19％（46/62）,高危型HPV感染率67.74％（42/62）,低危型HPV感染率58.06％（36/62）;HIV阴性组三者感染率分别为42.30％、29.57％、24.71％,两组比较,差异有统计学意义（均P＜ 0.01）.HIV阳性组男性HPV检出率高达92.11％（35/38）,和HIV阴性组男性检出率相比（37.38％,382/1 022）差异有统计学意义（x2=45.98,P＜0.01）.低危型HPV在HIV阳性组检出率前3位为HPV6（37.10％,23/62）、43和11型,在HPV阴性组检出率排序相同但HPV6的检出率仅11.12％（302/2 716）.高危型HPV在HIV阳性组检出率前5位依次是HPV16（22.58％,14/62）、52、66、58和18型,在HIV阴性组前5位依次为HPV16（7.77％,211/2 716）、58、56、66和52型.HPV亚型重叠感染情况,HIV阳性组最多八重,HIV阴性组最多九重,三重及以上感染者,HIV阳性组65.21％（30/46）,HIV阴性组16.71％（192/1 149）,差异有统计学意义.结论 HIV阳性人群HPV总感染率、高危型HPV感染率、低危型HPV感染率、男性HPV感染率以及HPV多重感染率均明显高出HIV阴性组,值得临床高度重视.Objective To compare the prevalence and genotype distribution of human papillomavirus （HPV） between human immunodeficiency virus （HIV）-positive and-negative populations.Methods Patients with condyloma acuminatum or persons who recently had sexual contact with patients with condyloma acuminatum were enrolled into this study,and classified into HIV-positive group （n =62） and HIV-negative group （n =2 716）.GeneChip analysis was performed to detect HPV and determine HPV genotypes in mucocutaneous samples collected from the external genitalia of these subjects.Statistical analysis was carried out by chi-square test using the SPSS software version 19.0.Results The prevalence rates of HPV infection,high-risk HPV types and low-risk HPV types were significantly higher in HIV-positive persons than in HIV-negative persons （74.19% （46/62） vs.42.30% （1 149/2 716）,67.74% （42/62） vs.29.57% （803/2 716）,58.06% （36/62） vs.24.71% （671/2 716）,respectively,all P〈 0.01）.The detection rate of HPV was also increased in HIV-positive men compared with HIV-negative men （92.11% （35/38） vs.37.38% （382/1 022）,x2 =45.98,P 〈 0.01）.Although the top three genotypes of low-risk HPV were types 6,43 and 11 in both HIV-positive and-negative groups,the prevalence rate of HPV 6 was 37.10% （23/62） in HIV-positive group,but only 11.12% （302/2 716） in HIV-negative group.The top five genotypes of high-risk HPV were types 16 （22.58%,14/62）,52,66,58 and 18 in HIV-positive group,and types 16 （7.77%,211/2716）,58,56,66 and 52 in HIV-negative group.Coinfections with multiple HPV subtypes were common in both groups,and the number of concurrent HPV genotypes was as high as 8 in HIV-positive group,and 9 in HIV-negative group.The prevalence rate of coinfections with three or more HPV genotypes in HIV-positive group was significantly higher than that in HIV-negative group （65.21% （30/46） vs.16.71% （192/1 149））.Conclusions Compared with HIV-negative populations,HIV-positive populati

关 键 词：HIV感染 乳头状瘤病毒感染 α乳头状瘤病毒属 重叠感染 

分 类 号：R512.91[医药卫生—内科学]