硫化氢的中枢心血管调节机制  

Role of hydrogen sulfide in central cardiovascular regulation

作　　者：赵胜兵[1] 谭兴[1] 王伟忠[1] 

机构地区：[1]第二军医大学基础部生理学教研室,上海200433

出　　处：《第二军医大学学报》2015年第2期193-200,共8页Academic Journal of Second Military Medical University

基　　金：国家自然科学基金(81070214;81170240;31100831);第二军医大学大学生创新能力培养基金(ZD2013019)~~

摘　　要：硫化氢(H2S)是继一氧化氮(NO)和一氧化碳(CO)之后的第3种内源性气体信号分子。研究显示H2S对神经系统、呼吸系统、消化系统和心血管系统具有调节效应,在正常生理功能和病理生理过程的调控中发挥重要生物学作用。近年来,H2S的中枢心血管调节作用逐渐引起重视,并表现出复杂的调节效果。本文主要介绍H2S对血压调节中枢相关核团的作用特点,并分析H2S在中枢心血管功能调控中的意义及其进展。Hydrogen sulfide（H2S）is the third endogenous gaseous mediator following nitric oxide and carbon monoxide.It has been demonstrated that H2 S plays important regulatory roles in modulating the physiological and pathophysiological processes of the nervous system,respiratory system,digestive system,and cardiovascular system.Recently,regulatory roles of H2 S in cardiovascular system are widely focused and seem to be complex.Here we sum up the roles of H2 S in mediating the cardiovascular regulation and illustrate its underlying mechanisms and perspectives.

关 键 词：硫化氢 心血管系统 孤束核 延髓头端腹外侧区 室旁核 

分 类 号：R311.3[医药卫生—基础医学]