医用全身正电子发射成像探测系统技术的研发热点和进展  

Recent Technical Research Hot Spots and Development Progresses in Medical Whole-body Positron Emission Tomography

作　　者：石涵(综述)[1,4] 都东(综述)[1] 苏志宏(综述)[2] 许剑锋(综述)[3] 邹怡蓉(综述)[1] 彭旗宇(审校) 

机构地区：[1]清华大学机械工程系,北京100084 [2]南方医科大学,广州510515 [3]华中科技大学机械科学与工程学院,武汉430074 [4]美国劳伦斯伯克利国家实验室生命科学部,CA94720

出　　处：《生物医学工程学杂志》2015年第1期218-224,共7页Journal of Biomedical Engineering

基　　金：国家国际科技合作专项资助项目(2013DFB30270);“数字制造装备与技术”国家重点实验室(华中科技大学)开放课题资助

摘　　要：医用全身正电子发射成像(PET)技术是最成功的分子影像技术之一,已经在肿瘤诊断、心血管疾病诊断和脑神经科学研究等领域得到了广泛的应用。然而,目前医用全身PET技术的系统灵敏度、空间分辨率和图像信噪比等方面还存在较大的不足和提升空间。系统灵敏度、空间分辨率和信噪比主要受晶体性能和晶体检测头设计的影响,而PET系统设计是在现有技术的基础上,通过对成像参数的平衡与优化,实现最佳的成像质量。随着闪烁晶体、光电传感器、高速电子系统等核心技术的发展,医用全身PET系统的性能有可能得到较大的提高。本文分析了相关技术的发展方向,并报告了最新进展。Medical whole-body positron emission tomography（PET）,one of the most successful molecular imaging technologies,has been widely used in the fields of cancer diagnosis,cardiovascular disease diagnosis and cranial nerve study.But,on the other hand,the sensitivity,spatial resolution and signal-noise-ratio of the commercial medical whole-body PET systems still have some shortcomings and a great room for improvement.The sensitivity,spatial resolution and signal-noise-ratio of PET system are largely affected by the performances of the scintillators and the photo detectors.The design of a PET system is usually a trade-off in cost and performance.A better image quality can be achieved by optimizing and balancing the key components which affect the system performance the most without dramatically increases in cost.With the development of the scintillator,photo-detector and high speed electronic system,the performance of medical whole-body PET system would be dramatically improved.In this paper,we report current progresses and discuss future directions of the developments of technologies in medical whole-body PET system.

关 键 词：正电子发射成像 灵敏度 空间分辨率 反应深度 飞行时间 

分 类 号：R445[医药卫生—影像医学与核医学]