舌下含服粉尘螨滴剂治疗不同严重程度变应性鼻炎患者的疗效分析  

Efficacy of sublingual immunotherapy with Dermatophagoides farinae drops on patients with allergic rhinitis of different symptom severity

作　　者：胡晓勋[1] 刘季萍[1] 付书彩[1] 韦永豪[1] 胡伟[1] 刘雅凌[1] 游锦[1] 张敏[1] 

机构地区：[1]江西九江学院附属医院耳鼻咽喉头颈外科,江西九江332000

出　　处：《临床耳鼻咽喉头颈外科杂志》2015年第3期223-225,共3页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

摘　　要：目的：探讨舌下含服粉尘螨滴剂治疗不同严重程度变应性鼻炎（AR）患者的疗效。方法：143例AR患者接受舌下特异性免疫治疗（SLIT）治疗1.5~2.0年,按疾病症状的严重程度不同分为中度组62例和重度组81例,评估不同严重程度AR患者在SLIT治疗前、治疗半年、1年及1.5~2.0年时的鼻部症状评分（TNSS）、药物评分（TMS）和体征评分变化。结果：与治疗前相比,SLIT治疗半年、1年、1.5~2.0年后,不同严重程度组AR患者的TNSS、TMS以及体征评分均显著改善（P〈0.05）;SLIT治疗前,重度组的TNSS和体征评分均显著高于中度组（Z=10.40、2.40,P〈0.05）,而用药评分差异无统计学意义（Z值为0.00,P〉0.05）;在治疗半年后,中度组与重度组之间的体征评分差异有统计学意义（Z=3.32,P〈0.05）,而TNSS和TMS差异无统计学意义（Z=1.58、0.37,P〉0.05）。在治疗1年及1.5~2.0年,中度组与重度组之间的TNSS、TMS以及体征评分差异均无统计学意义（P〉0.05）。结论：舌下含服粉尘螨滴剂对AR具有显著疗效,中度和重度AR患者最终都取得了相近的疗效。Objective： To evaluate the efficacy of sublingual immunotherapy （SLIT） with Dermatophagoides farinae drops for allergic rhinitis （AR） of different symptom severity. Method： This retrospective analysis to receive SLIT treatment of 143 cases of patients with allergic rhinitis, according to the severity of disease symptoms divid- ed into two groups, moderate group （62 patients） and severe group （81 patients）. Before SLIT and after SLIT for half year, 1 year and 1.5--2.0 years, the TNSS, TMS and sign scores of patients with allergic rhinitis were eval- uated. Result：The TNSS, TMS and sign scores had continuously improved significantly after SLIT for half year, 1 year and 1.5--2.0 years in two groups as compared with baseline （P〈0.05）. Before SLIT, TNSS and sign scores of severe group had a significantly higher level than moderate group （Z： 10. 40, 2. 40, P〈0. 05）, while TMS of two groups had no significant differences （Z= 0.00, P〉0.05）. Half year after SLIT treatment, in two groups for sign scores, there were significant differences （Z= 3.32, P〈0.05）, and there were no significant differences for TNSS （Z=1. 58,P〉0. 05） and TMS （Z=0. 37, P〉0. 05）. 1 and 1.5--2.0 years after SLIT, there were no significant differences in two groups for TNSS, TMS and sign scores （P〉0.05）. Conclusion： SLIT with Dermatophagoides farinae drops for 1.5--2.0 years is effective in the patients with allergic rhinitis of differ- ent symptom severity. And equivalent efficacy could be achieved for different symptom severity.

关 键 词：舌下特异性免疫治疗 鼻炎 变应性 疗效 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]