冠心病病人血清铁调素水平变化检测  

The change of hepcidin in patients with coronary heart disease

作　　者：王飞龙[1] 凌文华[1] 

机构地区：[1]中山大学公共卫生学院,广东广州510080

出　　处：《热带医学杂志》2015年第1期13-15,共3页Journal of Tropical Medicine

基　　金：国家自然科学基金(81130052)

摘　　要：目的探讨冠心病(CHD)患者血清铁调素的水平变化及其可能的意义。方法采用酶联免疫吸附法(ELISA)测定20例冠心病患者血清铁调素水平,并与20名健康体检者进行比较,分析血清铁调素水平的差异。结果冠心病患者血清铁调素浓度为(151.62±51.73)mmol/L,对照组血清铁调素浓度为(28.29±10.56)mmol/L,冠心病患者血清铁调素水平明显高于对照组,差异有统计学意义(P<0.05)。多重线性回归分析校正混杂因素后,差异仍然有统计学意义(P<0.05)。结论血清铁调素在冠心病病人血清中表达水平升高,提示血清铁调素可能在血管炎症反应及冠心病的发生和发展过程中起到重要的调节作用。Objective To explore the changes and clinical significance of serum hepcidin level in patients with coronary heart disease（CHD）. Methods By using enzyme-linked immunosorbent assay（ELISA）, serum hepcidin was measured in 20 patients with coronary heart disease and 20 controls. Results The serum level of hepcidin in coronary heart disease group was（151.62 ±51.73） mmol / L and was higher than that of the control group（28.29 ±10.56） mmol / L（t′ =10.446,P〈0.05）. The difference between the two groups still had statistically significant after the adjustment of confounders. Conclusion The increasing levels of serum hepcidin in the patients with coronary heart disease may play an important role in the severity of inflammation and the cause or development of coronary heart disease.

关 键 词：冠心病 铁调素 ELISA 

分 类 号：R541.4[医药卫生—心血管疾病]