重组人表皮生长因子在剖宫产术后促进伤口愈合的临床价值  

Clinical value of recombinant human epidermal growth factor on the wound healing after cesarean section

作　　者：付帅[1] 陈慧[1] 黄佩贤[1] 王蕴慧[1] 张睿[1] 张建平[1] 

机构地区：[1]中山大学孙逸仙纪念医院围产专科,广东广州510120

出　　处：《热带医学杂志》2015年第1期59-61,共3页Journal of Tropical Medicine

摘　　要：目的观察重组人表皮生长因子对促进剖宫产腹部切口愈合的疗效。方法选取通过剖宫产分娩的产妇300例,随机分为观察组和对照组,每组150例。观察组在缝合皮肤前及术后切口消毒时使用重组人表皮生长因子喷洒,对照组则常规关腹及消毒,两组均随访至产后3个月,观察切口愈合及产后疤痕增生情况。结果观察组出院时切口甲级愈合率明显高于对照组(99.3%vs 90.0%),差异有统计学意义(χ2=12.94,P<0.05)。术后3个月随访疤痕的优良率观察组明显高于对照组,差异有统计学意义(P<0.05)。结论剖宫产术关腹及术后切口清洁消毒时配合使用重组人表皮生长因子外用溶液,对促进创面愈合、减少感染、减少疤痕形成有一定的作用。Objective To observe the clinical value of recombinant human epidermal growth factor on the wound healing after cesarean section. Methods 300 women who undergone cesarean section were randomized into two groups ： treatment group（n =150） and control group（n =150）. For the treatment group, recombinant human epidermal growth factor was applied on the wound after suturing. The control group was treated with normal procedure after suturing. Results Compared with the control group, the healing rate of wound was significantly higher in the treatment group（99.3% vs 90.0%,P〈 0.05）. The treatment group showed better scars in the follow-up three months after the operation（84.7%, 5.3% vs 69.3%, 13.3%,respectively, P〈0.05）. Conclusion The usage of recombinant human epidermal growth factor after suturing showed a better effect on healing wound and could reduce the infection.

关 键 词：重组人表皮生长因子 剖宫产 腹部切口 疤痕 

分 类 号：R719.8[医药卫生—妇产科学]