人工周期在冻融胚胎移植周期中的应用价值  

Application value of artificial cycle in frozen-thawed embryo transfer cycles

作　　者：赵红岩[1] 杨爱军[1] 王钦[1] 王雪楠[1] 李瑞梅[1] 李晓云[1] 

机构地区：[1]山东济宁医学院附属医院生殖医学科,济宁272000

出　　处：《生殖医学杂志》2015年第2期107-110,共4页Journal of Reproductive Medicine

摘　　要：目的探讨人工周期子宫内膜准备方案对冻融胚胎移植(FET)妊娠结局的影响。方法募集接受FET的患者264例、共264个周期进行回顾性分析,按内膜准备方案不同予以分组:人工周期组177例(共177个周期),自然周期(NC)组72例(共72个周期)和促排卵周期组15例(共15个周期)。因促排卵周期组例数较少,故本文只对前两组即:人工周期组和自然周期(NC)组进行了比较分析。结果两组患者的年龄、不育年限、子宫内膜厚度、移植胚胎数、优质胚胎数、胚胎着床率、临床妊娠率等比较,均无显著性差异(P>0.05),但人工周期组胚胎着床率和临床妊娠率略高于自然周期组(27.0%vs.19.9%;42.9%vs.40.3%)。结论人工周期在胚胎着床率和临床妊娠率方面略高于自然周期,且前者方便并利于临床医师工作安排,因此人工周期可作为常规的子宫内膜准备方案。Objective： To explore the impact of artificial cycle on clinical pregnancy outcome in frozen-thawed embryo transfer cycle. Methods： The data of 264 frozen-thawed embryo transfer cycles were retrospectively analyzed. According to different endometrial preparation protocols, the cycles were divided into 3 groups： artificial cycle group（177 cycles）,nature cycle group（72 cycles）and ovulation induction group（15 cycles）. Because the cycle number of ovulation induction group was too less, the clinical outcomes were only compared between the other two groups. Results： There were no significant differences with regard to age, duration of infertility, endometrial thickness, number of embryos transferred, number of good-quality embryos, embryo implantation rate, clinical pregnancy rate between artificial cycle and nature cycle group（P〉0.05）. The implantation rate （27% vs. 19.9%）and clinical pregnancy rate in artificial cycle group（42.9% vs. 40. 3%）slightly higher than those in the natural cycle group,but there was no significant difference. Conclusions： The embryo implantation and clinical pregnancy of artificial cycle is slightly better than those of the natural cycle. The artificial cycle is convenient for patients and clinicians working arrangements,so it can be used as a routine endometrial preparation protocol.

关 键 词：人工周期 自然周期 冻融胚胎移植 

分 类 号：Q813.7[生物学—生物工程]