非选择性单胚胎移植的周期结局分析  

Analysis of Outcome of Non- elective Single Embryo Transfer Cycle

作　　者：朱春芳[1] 葛红山[1] 陈华[1] 习海涛[1] 黄检英[1] 吕杰强[1] 

机构地区：[1]温州医科大学附属第二医院生殖中心,325000

出　　处：《医学研究杂志》2015年第1期66-69,共4页Journal of Medical Research

基　　金：浙江省重点科技创新团队(2011R50013-17);浙江省自然科学基金资助项目(LQ12H04001)

摘　　要：目的 探讨非选择性单胚胎移植（non-elective single embryo transfer,non-eSET）的妊娠结局和相关因素对妊娠结局的影响.方法 回顾性分析2008年1月～2013年5月在笔者中心实施的体外受精-胚胎移植周期中行非选择性单胚胎移植的181个周期,分析不同的体外受精方式、胚胎质量和促排卵方案对非选择性单胚胎移植妊娠结局的影响.结果 非选择性单胚胎移植的临床妊娠率为12.71％.单精子胞质内注射（ICSI）组的正常受精率（2PN率）显著高于常规体外受精（IVF）组（75.48％ vs56.46％,P＜0.05）,但是临床妊娠率（16.36％ vs 11.11％,P＞0.05）差异无统计学意义;A级胚胎组的临床妊娠率（28.26％）显著高于B级胚胎组（9.52％）、C级胚胎组（6.89％）、D级胚胎组（6.25％）的各组临床妊娠率,差异有统计学意义（P＜0.05）.长方案组的临床妊娠率与微刺激组相比差异无统计学意义（16.39％ vs 14.29％,P＞0.05）,因此采用微刺激方案实施治疗可能具有更高的性价比.结论 非选择性单胚胎移植的临床妊娠率与胚胎质量相关.Objective To analyze the pregnant outcomes of non - elective single embryo transfer （ non - eSET） and investigate effect of related factors on the clinical pregnancy rate of non - eSET. Methods A retrospective analysis was carried out on in vitro fertili- zation - embryo transfer （IVF - ET） cycles between January 2008 and May 2013, and only one embryo was available to transfer in 181 cy- cles. The effect of diffenent insemination methods, embryo quality and different controlled ovarian hyperstimulation protocols was studied. Results The average clinical pregnancy rate was 12.71% in the 181 non- eSET cycles. The rate of 2PN in the intracytoplasmic sperm injection （ICSI） group was significantly higher than that in the IVF group（75.48% vs 56.46% , P 〈 0.05 ）. But the clinical pregnant rates（ 16.36% vs 11. 11% , P 〉 0.05 ）had no statistically significant difference. The clinical pregnancy rates were 28.26% , 9.52% , 6. 89% and 6.25% in the A embryo group, B embryo group, C embryo group and D embryo group respectively, and the clinical pregnan- cy rate of A embryo group was significantly higher than other three groups （ P 〈 O. 05 ）. The clinical pregnancy rate of the long protocol group was just a little higher than the mild stimulation protocol group（ 16.39% vs 14.29% , P 〉 O. 05 ） , so the the mild stimulation proto- col group may have higher cost - effectiveness. Conclusion The clinical pregnancy rate closely related to the embryo quality in the non - eSET cycles.

关 键 词：单胚胎移植 胚胎质量 临床妊娠率 

分 类 号：R71[医药卫生—妇产科学]