影响宫腔内人工授精妊娠率的相关因素分析  

Analysis on Relative Factors Affecting Pregnancy Rate of Intrauterine Insemination

作　　者：刘彩霞[1] 闻安民[1] 张仁礼[1] 韩冬[1] 周艳[1] 

机构地区：[1]广东省人民医院//广东省医学科学院生殖医学科,广东广州510080

出　　处：《中山大学学报（医学科学版）》2015年第1期135-139,共5页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：广东省自然科学基金(9151008004000030);广东省医学科研基金(A2012028)

摘　　要：【目的】探讨丈夫精子宫腔内人工授精(IUI)妊娠率的相关影响因素。【方法】回顾性分析不育不孕患者共1 382个IUI治疗周期,对处理后前向运动(PR)精子数、女方年龄、优势卵泡数、治疗方案、病因等因素与临床妊娠率的关系进行统计分析。【结果】1 382个IUI周期共获得167例临床妊娠,总周期妊娠率是12.1%。1PR精子数对妊娠率影响不大(P>0.05);2女性年龄超过40岁,妊娠率下降;32和3个优势卵泡妊娠率高于1个卵泡(P=0.001);4促排卵周期妊娠率高于自然周期(P=0.004),各促排卵方案之间差异无统计学意义;5排卵障碍患者的妊娠率最高为20.9%,与其他组间差异有统计学意义(P=0.001)。【结论】人工授精更适合于有排卵障碍的年轻患者。【Objective】 To investigate the various factors that affect clinical pregnancy rate following intrauterine insemination（IUI）.【Methods】 1382 cycles of intrauterine insemination were retrospectively analyzed.The correlation between pregnancy rate and following factors were analyzed including post-wash total progressive motile（PR） sperm count,female age,dominant follicle,different regimens and infertility etiology.【Results】 Pregnancy occurred in 167 cycles,resulting in an clinical pregnancy rate per cycle of 12.1%.1There was not a significant relationship between the sperm count of PR and pregnancy rate（P〈0.05）;2IUI pregnancy rate obviously declined when women of 40 years old;3The group with more than 2 dominant follicles had higher clinical pregnancy rate as compared with the single dominant follicle group.4 There was significant difference in pregnancy rate between natural cycle（NC） and stimulating cycle（SC） group（P = 0.004）.But the effects of the different regimes were not obviously different.5The clinical pregnancy rates（20.9） of the ovulation dysfunction group was significantly higher than those of other groups,and the difference was statistically significant（P = 0.001）.【Conclusion】 IUI is more suitable for patients with ovulation dysfunction and for those women of less than 40 years old.

关 键 词：宫腔内人工授精 妊娠率 影响因素 PR精子数 女性年龄 治疗方案 不孕病因 

分 类 号：R321.33[医药卫生—人体解剖和组织胚胎学] R711.6[医药卫生—基础医学]