丹参酮ⅡA对腹膜透析患者慢性炎症的调节作用  

Effect of TanshinoneⅡA on Microinflammation in Patients Undergoing Peritoneal Dialysis

作　　者：寿苗林[1] 李素波[1] 张小云[1] 

机构地区：[1]杭州市萧山区第一人民医院肾内科,311201

出　　处：《医学研究杂志》2015年第2期130-132,共3页Journal of Medical Research

摘　　要：目的 观察丹参酮ⅡA对腹膜透析患者慢性炎症的调节作用,并探讨其相关的临床意义.方法 收集2013年1月～ 2014年4月杭州市萧山区第一人民医院肾内科进行腹膜透析患者60例,随机分成常规腹膜透析对照组和丹参酮ⅡA注射液腹膜透析观察组,每组30例.比较两组相关临床和生化指标,IL-6、CRP表达的检测使用ELISA法.结果 两组治疗前IL-6、CRP、D/Pcr、KT/V、Ccr、尿量、超滤量、ALB、Ca、P、iPTH差异无统计学意义（P＞0.05）.治疗后对照组上述指标无显著性变化（P＞0.05）,但观察组IL-6、CRP较治疗前显著减低（P＜0.05）,D/Pcr、KT/V、Ccr、超滤量较治疗前显著性升高（P＜0.05）.观察组尿量、ALB、Ca、P、iPTH在治疗前与治疗后差异无统计学意义（P＞0.05）.结论 丹参酮ⅡA以显著抑制腹膜透析患者的微炎症状态,提高溶质清除率、肌酐透析液与血浓度之比和超滤量,有利于保护腹膜的转运功能.Objective To observe the effect of tanshinone ⅡA on microinflammation in patients undergoing peritoneal dialysis （PD） and explore its clinic significance. Methods Sixty cases of PD patients were enrolled in this study. All the patients were divided into： control group（n = 30） and tanshinone Ⅱ A observation group （n = 30）. The clinic and biochemical indicator were compared between the two groups. The IL -6 and CRP was detected by ELISA analysis. Results The IL -6, CRP, D/Pcr, KT/V, Ccr, urine volume, ultra- filtration volume, ALB, Ca, P, and iPTH bad no significant difference between the two groups before treatment （P 〉 0.05 ） ,which was not changed in control group after treatment （P 〉 0.05）. However, the IL - 6 and CRP was significantly decreased after treatment in ob- servation group （P .~ 0.05）. The D/Pcr, KT/V, Ccr, and ultrafihration volume was increased after treatment in observation group （P 〈 0.05 ）. The urine volume, ALB, Ca, P, and iPTH was not changed in observation group after treatment （P 〉 0.05）. Conclusion Tan- shinone Ⅱ A could significantly inbibitted microinflammation in patients undergoing PD,which could also improve the D/Pcr, KT/V, Ccr, and ultrafiltration volume.

关 键 词：丹参酮ⅡA 腹膜透析 微炎症状态 

分 类 号：R495.9[医药卫生—康复医学]