针刺结合耳穴贴压对经行头痛患者血清前列腺素F_(2α)及血浆血管加压素含量的影响  

Efficacy of acupuncture combined with auricular point sticking on the content of serum prostaglandin F_(2α) and plasma arginine vasopressin in patients with menstrual headache

作　　者：孙立虹[1,2] 梁玉磊[1] 李新华[1] 刘丽[3] 许晓康[1] 马红利[2,4] 李文丽[1] 石斐[2] 高飞[2] 

机构地区：[1]河北中医学院针灸推拿学院,石家庄050200 [2]河北医科大学 [3]河北师范大学医院 [4]河北省妇幼保健中心

出　　处：《中国针灸》2015年第2期137-140,共4页Chinese Acupuncture & Moxibustion

基　　金：河北省科技厅支撑计划项目:10276105D-33

摘　　要：目的:观察针刺结合耳穴贴压治疗经行头痛的临床疗效,并探讨其作用机制。方法:将85例经行头痛患者随机分为两组,观察组43例,采用体针与耳穴贴压并用的方法治疗;对照组42例,给予口服盐酸氟桂利嗪胶囊(西比灵)治疗,均治疗3个月经周期。观察两组的临床疗效,同时随机对两组部分患者治疗前后经期血清前列腺素F2α及血浆血管加压素含量进行检测,并同正常组20例进行比较。结果:观察组总有效率为95.4%(41/43),明显优于对照组的81.0%(34/42)(P<0.01)。治疗前两组患者血清前列腺素F2α、血浆血管加压素含量均较正常组高(均P<0.01);治疗后两组患者血清前列腺素F2α和血浆血管加压素含量均较治疗前降低(P<0.01,P<0.05);观察组血清前列腺素F2α含量较对照组降低明显(P<0.05),恢复至正常组水平。结论:体针联合耳穴贴压对经行头痛具有良好的疗效,其作用机制可能与调节异常的血清前列腺素F2α和血浆血管加压素水平有关。Objective To observe the clinical efficacy of acupuncture combined with auricular point sticking for menstrual headache and to discuss its mechanism. Methods Eighty-five patients with menstrual headache were randomly divided into an observation group （43 cases） and a control group（42 cases）. The observation group was treated with body acupuncture combined with auricular point sticking and the control group was treated with flunarizine hydrochloride capsules orally. The treatments of 3 menstrual cycles were required. The clinical efficacy was observed in the two groups. The content of serum prostaglandin F2α （PGF2α） and plasma arginine vasopressin （AVP） in the menstrual periods of some patients randomly selected in the two groups was tested before and after treatment and was compared with that of 20 cases in a normal group. Results The total effective rate was 95.4% （41/43） in the observation group which was obviously superior to 81. 0% （34/42） in the control group （P〈 0.01 ）. Before treatment, the content of serum PGF2, and plasma AVP of patients in the two groups was higher than that in the normal group （all P〈0.01）. After treatment,the content of serum PGF2α and plasma AVP was lower than that before treatment in the two groups（P〈0.01,P〈0.05）. The content of serum PGF2α in the observation group was decreased significantly compared with that in the control group（P〈0.05） and returned to the level of the normal group. Conclusion Body acupuncture combined with auricular point sticking achieves positive efficacy for menstrual headache and its mechanism could be related to regulating the abnormal levels of serum PGF2α and plasma AVP.

关 键 词：经行头痛 肝火旺盛型 针刺 耳穴贴压 前列腺素F2Α 血管加压素 

分 类 号：R246.3[医药卫生—针灸推拿学]