兰尼碱受体2参与重大心脏疾病发生发展机制的研究进展  

Mechanisms of ryanodine receptor 2 in serious cardiac disease development and progression: research advances

作　　者：王智超[1] 蒋雅楠[1] 白云龙[1] 

机构地区：[1]哈尔滨医科大学药理学教研室,黑龙江哈尔滨150081

出　　处：《中国药理学与毒理学杂志》2015年第1期105-110,共6页Chinese Journal of Pharmacology and Toxicology

基　　金：黑龙江省教育厅科学技术研究项目(12511317);哈尔滨医科大学药学院大学生创新基金项目~~

摘　　要：心血管疾病是全球范围内首要的致死原因,严重威胁人类的生命健康。兰尼碱2受体(RyR2)是心肌细胞肌浆网上重要的钙释放通道,其调控机制复杂,一些相关研究仍存在争议。RyR2的基因突变、结构改变、功能障碍或与相关蛋白的相互作用异常均可造成RyR2受体的钙释放阈值降低,引起肌浆网钙异常释放,诱发或加重多种心脏疾病。以RyR2为靶点的药物对心脏疾病很可能具有治疗作用。一种针对RyR2靶点的新药已进入Ⅱ期临床试验,随着RyR2结构、功能及作用机制研究的进一步深入,必将为心血管疾病的早期诊断、鉴别、药物研发等提供更加准确可靠的信息。本文就RyR2参与重大心脏疾病发生与发展机制的研究进行综述。Cardiovascular diseases are the leading cause of death globally,and pose serious a threat to human health and lives. Ryanodine receptor 2（ RyR2） is an important cardiac calcium release channel. The regulatory mechanisms of RyR2 are complex and some related researches remain controversial. RyR2 gene mutations,structure changes,functional disorders or abnormal interaction between its related proteins can induce sarcoplasmic reticulum calcium leakage,involved in the generation and progression of a variety of cardiac diseases. Drugs that target RyR2 can be of therapeutic significance in cardiac diseases. Moreover,a new drug that targets RyR2 has just entered into phaseⅡ of clinical trials. In alignment with the frontline research of life sciences,information on the structural formula of RyR2 and its mechanism and function is one step closer to being made known. Inevitably,this helps diagnose and distinguish the early stages of cardiovascular diseases and contributes to the research and development of pharmaceutical drugs by providing even more accurate and reliable information. This review will discuss the mechanisms of RyR2 in serious cardiac diseases.

关 键 词：兰尼碱受体钙释放通道 心律失常 心肌缺血 心肌病 肥厚性 心力衰竭 充血性 

分 类 号：R541[医药卫生—心血管疾病]