同卵双生活体部分小肠移植一例报告  

The living-related intestinal transplantation between identical twins： A case of report

作　　者：吴国生[1] 赵青川[1] 王为忠[1] 施海[1] 王勉[1] 陈冬利[1] 郑建勇[1] 赵正维[1] 李孟彬[1] 赵海红[1] 朱波峰[2] 于卫华[3] 李增山[4] 

机构地区：[1]第四军医大学西京消化病医院消化外科,西安710032 [2]西安交通大学医学院法医学院 [3]第四军医大学西京消化病医院消化科内镜中心 [4]第四军医大学西京消化病医院病理科

出　　处：《中华器官移植杂志》2015年第1期30-33,共4页Chinese Journal of Organ Transplantation

基　　金：国家自然科学基金面上项目（81170440）

摘　　要：目的总结成功实施的一例同卵双生之间活体部分小肠移植的手术经验。方法受者为45岁女性，因肠系膜上动脉栓塞导致短肠综合征；供者为其同卵双胞胎姐姐。术前经短串联重复序列检测证实供、受者为同卵双生。取供者远端回肠155cm作为移植肠。术中及术后受者使用短期激素治疗，之后停用免疫抑制剂。结果小肠移植手术顺利，术后供、受者均无并发症，受者12d后出院并恢复正常饮食。随访12个月，供、受者情况良好。结论同卵双生小肠移植是治疗短肠综合征的理想方法。Objective We described one case of successful living-related intestine transplant between identical twins. Method The recipient was a 45 yeaPold female with short gut syndrome secondary to superior mesenteric artery thrombosis. Monozygosity was established by buecal smear DNA PCR amplification using short tandem repeat. The recipient, who was transplanted with 155 cm of the donor distal ileum, had an uneventful postoperative course and was discharged on a regular diet 12 days after surgery. Result Posttransplantively, she received a brief course of steroids without maintenance immunosuppression. At 12-month follow-up, both donor and recipient were well without complications. Conclusion Living-related intestinal transplant between identical twins can be a valid therapeutic option for the management of short gut syndrome.

关 键 词：活体供者 小肠移植 双生 单卵 短肠综合征 

分 类 号：R656.7[医药卫生—外科学]