白细胞介素21受体mRNA的表达与检测对类风湿关节炎患者的临床应用价值  

Clinical Expression and Detection of Interleukin-21 Receptor mRNA on Rheumatoid Arthritis

作　　者：杨晓东[1] 卢建明[1] 饶丽华[1] 吴大富[1] 

机构地区：[1]三峡大学仁和医院检验科,湖北宜昌443001

出　　处：《医学综述》2015年第3期513-514,共2页Medical Recapitulate

摘　　要：目的探讨白细胞介素21受体信使RNA的表达与检测对类风湿关节炎患者的临床应用价值。方法选取2012年3月至2014年4月在三峡大学仁和医院进行检验和治疗的类风湿关节炎患者80例,设为观察组,另外根据一般资料相近原则选择30例健康志愿者作为对照组,根据患者关节功能分为3个等级,分别采样后比较白细胞介素21(IL-21)受体信使RNA的表达情况。结果观察组患者IL-21水平为(510±66)ng/L,明显高于对照组的(333±30)ng/L(t=13.80,P<0.05);三级类风湿性关节炎患者体内IL-21水平分别为Ⅰ级(410±57)ng/L,Ⅱ级(436±60)ng/L,Ⅲ级及以上(601±79)ng/L,三个等级比较差异有统计学意义(F=14.01,P<0.05),其中Ⅰ级与Ⅱ级的差异无统计学意义(t=1.33,P>0.05),Ⅱ级与Ⅲ级及以上患者的差异有统计学意义(t=8.53,P<0.05),Ⅰ级与Ⅱ级以上比较差异有统计学意义(t=10.22,P<0.05)。结论 IL-21参与了类风湿关节炎的发病过程,故该物质的水平可用于疾病的检测,具有广阔的应用前景。Objective To investigate the clinical application value of the expression and detection of mRNA of interleukin-21 receptor in patients with rheumatoid arthritis. Methods A total of 80 patients with rheumatoid arthritis from China Three Gorges University Renhe Hospital from Mar. 2012 to Apr. 2014 were selected as the observation group,another 30 healthy volunteers were selected as the control group based on the related data of physical examination. According to the joint function,the patients was divided into three grades,the expression of interleukin 21 receptor mRNA sampling was compared. Results In the observation group,IL-21 level was（ 510 ± 66） ng / L,significantly higher than that of the healthy control group [（ 333 ±30 data） ng / L]（ t = 13. 80,P 0. 05）; the in vivo IL-21 levels of three grades were（ 410 ± 57） ng / L,（ 436 ± 60） ng/L,（ 601 ± 79） ng/L respectively for grade Ⅰ,Ⅱ,Ⅲ and above,the differences were statistically significant（ F = 14. 01,P 0. 05）,between grade Ⅱ and Ⅰ there was no statistically significant difference（ t = 1. 33,P 0. 05）,while between grade II and grade III or above there was statistically significant difference（ t = 8. 53,P 0. 05）. Conclusion IL-21 is involved in the pathogenesis of rheumatoid arthritis,therefore the level of IL-21 can be used in the disease detection,and has broad application prospects.

关 键 词：类风湿关节炎 白细胞介素21受体 酶联免疫吸附试验 

分 类 号：R722.1[医药卫生—儿科]