调节性B细胞的发现、起源和分化及激活  

The Discovery,Origin,Differentiation and Activation of Regulatory B Cells

作　　者：张怡舜[1] 陈思娇[2] 宋今丹[2] 

机构地区：[1]中国医科大学附属第一医院老年病教研室,沈阳110001 [2]中国医科大学医学分子生物学研究所卫生部细胞生物学重点实验室,沈阳110001

出　　处：《医学综述》2015年第4期608-609,共2页Medical Recapitulate

摘　　要：B细胞的主要功能是分泌抗体和呈递抗原,并以此起始和活化免疫系统发挥正性调节作用。新近研究表明,一类具有负性免疫调节功能的B细胞亚群——调节性B细胞(Gregs)可通过细胞间直接接触和分泌白细胞介素10等方式下调免疫应答。Bregs在许多疾病中发挥着重要的调节作用。Bregs的发现、起源、分化将为全面、深入了解自身免疫病免疫耐受的机制,及寻找更合理的自身免疫病治疗方法提供理论依据和新的研究方向。The main function of B cells is secreting antibodies,antigen presentation and activating the immune system,so B cells play a positive regulatory role in immune responses. Recent studies have shown that there is a B cell subset with the function of negative regulation-regulatory B cells（ Bregs）.They can down regulate the immune reaction through direct contact with other immune cells or secretion of IL-10 etc. At the same time,Bregs play an important regulatory role in many diseases. The discovery,origin,differentiation and activation of regulatory B cells will provide the theory basis and the new research direction for the comprehensive,in-depth understanding of immune tolerance mechanisms of autoimmune disease,and for the more reasonable treatment of autoimmune diseases.

关 键 词：调节性B细胞 来源 分化 自身免疫病 

分 类 号：R34[医药卫生—基础医学]