超高效液相色谱法快速测定轻工产品中三种吡咯酮的研究  

Rapid Determination of Three Pyrrolidones in Light Industrial Products by Ultra Performance Liquid Chromatography

作　　者：俞凌云[1] 吴孟茹 金晶[1] 温演庆[1] 车颖欣 董伟[1] 

机构地区：[1]四川出入境检验检疫局检验检疫技术中心,四川成都610041

出　　处：《皮革与化工》2015年第1期5-7,15,共4页Leather And Chemicals

基　　金：质检科研项目(2014IK161);四川局科研项目(SK201415);质检公益性项目(201310066)

摘　　要：2-吡咯烷酮(PYR)、N-甲基吡咯烷酮(NMP)、N-乙基吡咯烷酮(NEP)是一类优良的有机溶剂,因其潜在的生殖毒性而被关注。本文利用超高效液相色谱-二极管阵列检测器建立检测皮革中PYR、NMP、NEP的简单方法,样品提取方法为40℃超声水浴提取,提取溶液为0.1%十二烷基磺酸钠水溶液。在优化的色谱条件下,三种吡咯酮的检出限在20μg/L^40μg/L,其回收率高于91.6%。这个方法被成功应用于测定轻工产品中的2-吡咯烷酮、N-甲基吡咯烷酮和N-乙基吡咯烷酮,比传统的气相色谱法准确度高,且提取步骤简单。2- pyrrolidone（PYR）, N- methyl pyrrolidone（NMP） and N- ethyl pyrrolidone（NEP） are a kind of excellent organic solvent, which have been focused on because of their potential reproductive toxicity. A simple method followed by ultra performance liquid chromatography（UPLC） with Photo- Diode Array detector（PDA） has been developed for the determination of 2- Pyrrolidone,N- methyl pyrrolidone and N- ethyl pyrrolidone in leather samples. 0.1% sodium dodecyl sulfonate aqueous solution was used for the ultrasonic extraction at 40℃. Under optimal conditions, the quantification limits for the desired compounds ranging from 20 to 40μg/L were obtained. The recoveries were higher than 91.6%. The proposed method was successfully applied to the determination of the target compounds in light industrial products with a higher sensitivity and simpler extraction than traditional gas chromatography methods.

关 键 词：超高效液相色谱 α- 吡咯烷酮 N-甲基吡咯烷酮(NMP) N-乙基吡咯烷酮 轻工产品 

分 类 号：TQ251.3[化学工程—有机化工] O657.72[理学—分析化学]