吸氧对听感觉门控P50的影响  

Effect of Oxygen Inhalation on Auditory Sensory Gating P50

作　　者：于秋红[1] 陈昭燃[2] 张红霞[1] 刘亚玲[1] 薛连璧[1] 

机构地区：[1]首都医科大学附属北京天坛医院高压氧科,北京市100050 [2]首都医科大学神经生物系高级脑功能中心,北京市100069

出　　处：《中国康复理论与实践》2015年第2期153-156,共4页Chinese Journal of Rehabilitation Theory and Practice

基　　金：国家自然科学基金项目(No.30972829)

摘　　要：目的研究呼吸纯氧对健康人听感觉门控P50的影响。方法右利手、健康男性大学生志愿者28名,根据随机数字表分为对照组(n=12)和实验组(n=16)。佩戴面罩,对照组呼吸空气,实验组呼吸医用纯氧60 min。应用条件-测试刺激,记录吸氧前(pre0)、吸氧20 min(Oxy20)、吸氧50 min(Oxy50)、吸氧后30 min(post30)的脑电图,计算听觉P50潜伏期和P50感觉门控电位(S1与S2振幅之差)。结果 S1刺激在4个时间点各组P50潜伏期相对稳定(P>0.7);吸氧50 min时,实验组比对照组P50潜伏期缩短(P<0.05)。S2刺激在4个时间点各组P50潜伏期相对稳定(P>0.30),两组间比较无显著性差异(P>0.05)。对照组P50门控电位比较稳定(P=0.70),而实验组随吸氧时间逐渐延长,电位越来越高,停止吸氧后,电位迅速回落,Oxy20和post30(P=0.04)、Oxy50和post30(P=0.02)相比均有显著性差异。组间比较,4个时间点均无显著性差异(P>0.05)。结论健康人吸60 min纯氧,可能缩短对刺激的反应时间,有增强听觉门控电位的趋势。Objective To explore the effect of oxygen inhalation on auditory sensory gating P50 in healthy human brain. Methods 28 healthy male academician right-handed were included. They were divided into control group（n=12） and experiment group（n=16） according to the random numerical table, and blinded about groups. The subjects inhaled pure oxygen in the experiment group, and air in the control group through a mask for 60 min. The electroencephalograph was recorded while an auditory paired-click sensory gating test was conducted during 4 study periods： before inhalation（pre0）, inhale for 20 min（Oxy20） and 50 min（Oxy50）, and 30 min after inhalation（post30）. The latency and amplitude（S1- S2） of auditory sensory gating P50 were calculated. Results The latencies of P50 from S1 were stable in each group（P〉0.7）, and the latency of Oxy50 was shorter in the experiment group than in the control group（P〉0.05）. The latencies from S2 were stable in each group（P〉0.30）, and there was no significant difference between groups in all the time points（P〈0.05）. The amplitudes of（S1-S2） of P50 were stable in the control group（P=0.70）, and was higher on Oxy20（P=0.04） and Oxy50（P=0.02） than post30 in the experiment group. There was no difference between the groups in all the time points（P〉0.05）. Conclusion Oxygen inhalation may be helpful to shorten the active time to stimulate, and trend to enhancing the amplitude of P50.

关 键 词：吸氧 听感觉门控 P50 

分 类 号：R459.6[医药卫生—治疗学]