“补肾生髓成肝”改善肝再生微环境、防治肝癌的作用及机制  

Tonifying Kidney Network to Modulate Liver Regeneration Microenvironment to Prevent and Cure Liver Cancer

作　　者：李瀚旻[1] 赵宾宾[2] 高翔[1] 沈昕[3] 吴雨[2] 张金荣[2] 宋红丽[2] 叶之华[2] 程思思[2] 

机构地区：[1]湖北中医药大学附属医院肝病研究所,湖北武汉430061 [2]湖北中医药大学 [3]湖北中医药大学免疫教研室,湖北武汉430065

出　　处：《湖北中医药大学学报》2015年第1期5-8,共4页Journal of Hubei University of Chinese Medicine

基　　金：国家自然科学基金(81373513;90709041;30672590;30271562;30371787;81102531;81274147);国家科技部重大基础研究项目("973"项目;2002CCC00300);国家中医临床研究基地(湖北)重点病种研究项目(JDZX2012054);国家"十二五"重大专项(2012ZX10005005-001-015);国家中医药管理局国家中医临床研究基地(湖北)重点病种研究项目(JDZX2012054);湖北省自然科学基金重点项目(2011CDB463);高等学校博士学科点专项科研基金项目(20124230110001);武汉市科技局科技攻关武汉市重大科技产业化专项项目(201260523199)

摘　　要：肝再生微环境影响肝癌的发生发展是近些年来的新认识,改善肝再生微环境是防治肝癌的新策略。"补肾生髓成肝"改善肝再生微环境,防治肝癌的发生发展,已具有较高级别的循证医学证据,通过下丘脑-垂体-肝轴、神经-内分泌-免疫-肝再生调控网络、骨髓干细胞转化为肝脏细胞等途径,改善肝再生微环境可能是"补肾生髓成肝"防治肝癌的疗效机制。In recent years,a new understanding has been recognized that the microenvironment of liver regeneration can affect the occurrence and development of liver cancer. Therefore,to prevent and treat liver cancer by improving the liver regeneration of microenvironment is the new strategy. Furthermore,the strategy of ＂tonifying the kidney to promote liver regeneration and repair by effecting stem cells and it＇s microenvironment＂（ ＂TTKESC＂） to prevent and treat liver cancer by improving the liver regeneration of microenvironment has occurred with a higher level of evidence based medicine. what＇s more,to improve the microenvironment of liver regeneration via regulating the axis of hypothalamic- pituitary- liver,the network of neuro- endocrine- immune- liver regeneration,and the course of bone marrow stem cells transforming into liver cells may be the efficacy mechanism of ＂TTKESC＂for prevention and treatment of liver cancer.

关 键 词：补肾生髓成肝 肝再生微环境 肝癌 

分 类 号：R259[医药卫生—中西医结合]