HPA轴与2型糖尿病发病机制相关性的研究  

Study On Pathogenesis Relationship Between Hypothalanus- pituitary- adrenal Axis and Type 2 Diabetes

作　　者：高珊[1] 李瑞 田环环[1] 曹昺焱[1] 裴恩实 黄英恒 刘锦龙[1] 武燕[1] 

机构地区：[1]北京中医药大学针灸推拿学院,北京100029

出　　处：《湖北中医药大学学报》2015年第1期113-116,共4页Journal of Hubei University of Chinese Medicine

基　　金：教育部科学技术研究重大项目(313010)

摘　　要：下丘脑-垂体-肾上腺轴(HPA轴)作为一个重要的反馈调节系统,是神经内分泌网络的的枢纽,不仅对维持机体内环境的平衡起着重要的作用,而且参与衰老、应激等病理生理过程的调节。国内外研究发现,T2DM患者多伴有HPA轴的活性增强及皮质醇分泌增多的表现。本研究就HPA轴的功能变化与2型糖尿病的关系在机制研究方面进行文献综述。The hypothalamus- pituitary- adrenal axis（ HPA） as an important part of the feedback control system is the pivot of neuroendocrine network. It plays an important role not only in keeping balance of body internal environment,but also in regulation of some pathophysiological process such as aging and stress. The domestic and foreign researches foud that patients with Type 2 DM had hyperactivity of HPA axis and increased cortisol secretion. This paper is a literature review on the relationship of diabetes mellitus and the functional change of the hypothalamus- pituitary- adrenal axis from the mechanism point of view.

关 键 词：糖尿病 2型 HPA轴 综述 

分 类 号：R587.1[医药卫生—内分泌]