Synthesis and Characterization of Novel Azo-containing or Azoxy-containing Schiff Bases and Their Antiproliferative and Cytotoxic Activities  

作　　者：SU Ran LU Lei ZHENG Songzhi JIN Yinghua AN Shengji 

机构地区：[1]College of Chemistry [2]College of Life Science, Jilin University, Changchun 130012, P. R. China

出　　处：《Chemical Research in Chinese Universities》2015年第1期60-64,共5页高等学校化学研究（英文版）

摘　　要：A series of novel Schiff base derivatives was designed and synthesized from 3,3＇-azobenzaldehyde and 3,3＇-azoxybenzaldehyde. The newly synthesized compounds were characterized by FTIR, ^1H NMR, MS and elemental analysis and tested for their in vitro antiproliferative activities against HeLa cell lines. At the same time, the impact on the antitumor activity of the sulfanilamido, benzamido, phenolic hydroxyl or thiourea groups was investigated and discussed. Compounds 4, 6 and 10 were found to exhibit strong cytotoxic activity.A series of novel Schiff base derivatives was designed and synthesized from 3,3＇-azobenzaldehyde and 3,3＇-azoxybenzaldehyde. The newly synthesized compounds were characterized by FTIR, ^1H NMR, MS and elemental analysis and tested for their in vitro antiproliferative activities against HeLa cell lines. At the same time, the impact on the antitumor activity of the sulfanilamido, benzamido, phenolic hydroxyl or thiourea groups was investigated and discussed. Compounds 4, 6 and 10 were found to exhibit strong cytotoxic activity.

关 键 词：Schiffbase AZO Azoxy Anti-proliferative activity Cytotoxic activity 

分 类 号：TQ464.2[化学工程—制药化工] O625.632[理学—有机化学]