Synthesis and Biological Evaluation of Novel Saccharin Derivatives Containing 1,2,3-Triazole Moiety  

作　　者：TANG Xiaobin LI Zhenghui LI Yonghong LIU Wei YU Peng LI Lixin GUO Yu YANG Cheng 

机构地区：[1]College of Biotechnology [2]College of Sciences, Tianjin University of Science and Technology, Tianjin 300457, P. R. China [3]State Key Laboratory of Element Organic Chemistry, Institute of Element Organic Chemistry [4]College of Pharmacy, Nankai University, Tianjin 300071, P. R. China [5]High Throughput Molecular Drug Discovery Center, Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin 300457, P. R. China

出　　处：《Chemical Research in Chinese Universities》2015年第1期71-77,共7页高等学校化学研究（英文版）

基　　金：Supported by the National Natural Science Foundation of China（No.21302139）.

摘　　要：A series of novel saccharin derivatives containing 1,2,3-triazole moiety was synthesized in satisfactory yields. The structures of all the compounds were elucidated and confirmed by Fourier transform infrared（FTIR） spectroscopy, ^1H and ^13C nuclear magnetic resonance（^1H NMR, ^13C NMR） spectroscopy, and high resolution mass spectrometry（HRMS）. The bioassays indicated that most of the title compounds displayed some extent herbicidal activities at 100 μg/mL.A series of novel saccharin derivatives containing 1,2,3-triazole moiety was synthesized in satisfactory yields. The structures of all the compounds were elucidated and confirmed by Fourier transform infrared（FTIR） spectroscopy, ^1H and ^13C nuclear magnetic resonance（^1H NMR, ^13C NMR） spectroscopy, and high resolution mass spectrometry（HRMS）. The bioassays indicated that most of the title compounds displayed some extent herbicidal activities at 100 μg/mL.

关 键 词：SACCHARIN 1 2 3-TRIAZOLE Biological activity Herbicidal 

分 类 号：O626.26[理学—有机化学] TS264.9[理学—化学]