山羊角替代羚羊角的实验研究  

Experimental study on horns of Capra hircus instead of horns of Saiga tataria

作　　者：陈芙蓉[1] 商丹丹[2] 姜溪[1] 只德广[1] 岳南[1] 刘彤[2] 

机构地区：[1]天津药物研究院新药评价有限公司,天津300193 [2]天津中新药业集团股份有限公司达仁堂制药厂,天津300475

出　　处：《药物评价研究》2015年第1期49-52,共4页Drug Evaluation Research

摘　　要：目的通过抗惊厥和解热实验,研究山羊角对羚羊角的替代比例范围,为山羊角替代羚羊角的应用提供依据。方法采用戊四唑致小鼠惊厥实验,观察两者对惊厥时间和死亡率的影响,并分别作量效关系图;采用干酵母致大鼠发热实验,比较两者对大鼠温度升高的抑制作用,并分别作量效关系图。结果羚羊角能延长小鼠惊厥的潜伏期,降低死亡率;羚羊角和山羊角能不同程度地抑制大鼠体温的升高。两模型的替代比例分别为6.0∶1与7.2∶1。结论山羊角替代羚羊角的比例范围为（6.0∶1~7.2∶1）。Objective To provide the basis for application that replacement ratio range between horns of Capra hirus and horns of Saiga tataria, anticonvulsants and antipyretic experiment were arranged. Methods Anticonvulsants experiment induced by pentylenetetrazole in mice was arranged to observe the effects of two drugs on convulsion time and mortality, and respectively concentration-response relationship diagram was drawn. Antipyretic experiment induced by yeast was arranged to observe the inhibition of rapid temperature rise of two drugs, and concentration-response relationship diagram was drawn respectively. ResultsHorns of Saiga tataria can extend the latent period of convulsion and reduce the mortality rate; Horns of Capra hirus can inhibit the rising of body temperature in different degrees. Two models of replacement ratio were 6.0：1 and 7.2：1, respectively. Conclusion The ratio range of horns of Capra hirus instead of horns of Saiga tataria is 6.0：1—7.2：1.

关 键 词：山羊角 羚羊角 惊厥 发热 

分 类 号：R282[医药卫生—中药学]