连花清瘟胶囊带式真空干燥工艺优化研究  

Study on the Optimization of Belt Vacuum Drying Technology for Lianhua Qingwen Capsules

作　　者：苏红宁[1] 王玉峰[2] 李淳瑞 刘敏彦[2] 李向军[2] 范文成[2] 

机构地区：[1]石家庄市第四医院,石家庄050011 [2]石家庄以岭药业股份有限公司,石家庄050035

出　　处：《中国药房》2015年第7期964-966,共3页China Pharmacy

基　　金：国家科技重大专项--重大新药创制(No.2011ZX09201-201-27)

摘　　要：目的：优化连花清瘟胶囊带式真空干燥的关键工艺参数。方法：以干浸膏的水分以及有效成分（连翘酯苷A、绿原酸）含量为评价指标，对影响真空干燥的主要因素（干燥温度、加料速度、履带速度）进行优选及验证试验。结果：优选干燥工艺参数为干燥温度50-60℃，加料速度20L／h，履带速度18cm／min。2次验证试验结果表明，干燥后干浸膏的水分、连翘酯苷A含量、绿原酸含量分别为4．8％、4．6％，1．76、1．78mg／g，5．04、4．95mg／g。结论：优选后的真空带式干燥工艺稳定、可行。OBJECTIVE： To optimize the key parameters of belt vacuum drying technology for Lianhua qingwen capsules. METHODS： The key impact factors of vacuum drying as drying temperature, feed rate and track speed were optimized and veri- fied using the moisture content of dry extract, forsythiaside A and chlorogenic acid as evaluation index. RESULTS： The parameters of optimized vacuum belt drying technology were as drying temperature of 50-60 ~C, the feed rate of 20 L/h and the track speed of 18 cm/min. The results of 2 verification tests showed that after drying, the moisture content of dry extract and the content of forsy- thiaside A and chlorogenic acid were 4.8%, 4.6% ; 1.76 mg/g, 1.78 mg/g; 5.04 mg/g, 4.95 mg/g, respectively. CONCLUSIONS： The optimized vacuum belt drying technology is stable and feasible.

关 键 词：连花清瘟胶囊 带式真空干燥技术 干燥工艺 优化 水分 连翘酯苷A 绿原酸 含量 

分 类 号：R283[医药卫生—中药学]